node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDH4A1 | GAD1 | ENSBTAP00000059236 | ENSBTAP00000009547 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity). | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family. | 0.933 |
ALDH4A1 | GLS | ENSBTAP00000059236 | ENSBTAP00000010348 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity). | Glutaminase. | 0.910 |
ALDH4A1 | GLS2 | ENSBTAP00000059236 | ENSBTAP00000012233 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity). | Glutaminase 2. | 0.956 |
ALDH4A1 | GLUD1 | ENSBTAP00000059236 | ENSBTAP00000009923 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity). | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.964 |
ALDH4A1 | GLUL | ENSBTAP00000059236 | ENSBTAP00000057244 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity). | Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating [...] | 0.940 |
CAD | CPS1 | ENSBTAP00000023783 | ENSBTAP00000022158 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Carbamoyl-phosphate synthase 1. | 0.904 |
CAD | GAD1 | ENSBTAP00000023783 | ENSBTAP00000009547 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family. | 0.867 |
CAD | GFPT1 | ENSBTAP00000023783 | ENSBTAP00000023441 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutamine--fructose-6-phosphate transaminase 1. | 0.926 |
CAD | GFPT2 | ENSBTAP00000023783 | ENSBTAP00000002867 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins (By similarity). | 0.926 |
CAD | GLS | ENSBTAP00000023783 | ENSBTAP00000010348 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutaminase. | 0.901 |
CAD | GLS2 | ENSBTAP00000023783 | ENSBTAP00000012233 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutaminase 2. | 0.914 |
CAD | GLUD1 | ENSBTAP00000023783 | ENSBTAP00000009923 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.850 |
CAD | GLUL | ENSBTAP00000023783 | ENSBTAP00000057244 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating [...] | 0.960 |
CAD | PPAT | ENSBTAP00000023783 | ENSBTAP00000047788 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.988 |
CPS1 | CAD | ENSBTAP00000022158 | ENSBTAP00000023783 | Carbamoyl-phosphate synthase 1. | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | 0.904 |
CPS1 | GLS | ENSBTAP00000022158 | ENSBTAP00000010348 | Carbamoyl-phosphate synthase 1. | Glutaminase. | 0.915 |
CPS1 | GLS2 | ENSBTAP00000022158 | ENSBTAP00000012233 | Carbamoyl-phosphate synthase 1. | Glutaminase 2. | 0.924 |
CPS1 | GLUD1 | ENSBTAP00000022158 | ENSBTAP00000009923 | Carbamoyl-phosphate synthase 1. | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.985 |
CPS1 | GLUL | ENSBTAP00000022158 | ENSBTAP00000057244 | Carbamoyl-phosphate synthase 1. | Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating [...] | 0.969 |
CPS1 | PPAT | ENSBTAP00000022158 | ENSBTAP00000047788 | Carbamoyl-phosphate synthase 1. | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.744 |