node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABHD17B | PPME1 | ENSBTAP00000008957 | ENSBTAP00000039548 | Abhydrolase domain containing 17B. | Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity); Belongs to the AB hydrolase superfamily. | 0.741 |
CIP2A | LCMT1 | ENSBTAP00000022784 | ENSBTAP00000037258 | Cell proliferation regulating inhibitor of protein phosphatase 2A. | Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. | 0.602 |
CIP2A | PPME1 | ENSBTAP00000022784 | ENSBTAP00000039548 | Cell proliferation regulating inhibitor of protein phosphatase 2A. | Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity); Belongs to the AB hydrolase superfamily. | 0.777 |
CIP2A | PPP2CA | ENSBTAP00000022784 | ENSBTAP00000000596 | Cell proliferation regulating inhibitor of protein phosphatase 2A. | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). Belongs to the PPP phosphatase family. PP-1 subfamily. | 0.439 |
CIP2A | PPP2R1A | ENSBTAP00000022784 | ENSBTAP00000026449 | Cell proliferation regulating inhibitor of protein phosphatase 2A. | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis. | 0.432 |
CIP2A | PPP2R5E | ENSBTAP00000022784 | ENSBTAP00000059991 | Cell proliferation regulating inhibitor of protein phosphatase 2A. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Belongs to the phosphatase 2A regulatory subunit B56 family. | 0.411 |
LCMT1 | CIP2A | ENSBTAP00000037258 | ENSBTAP00000022784 | Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. | Cell proliferation regulating inhibitor of protein phosphatase 2A. | 0.602 |
LCMT1 | PPME1 | ENSBTAP00000037258 | ENSBTAP00000039548 | Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. | Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity); Belongs to the AB hydrolase superfamily. | 0.924 |
LCMT1 | PPP2CA | ENSBTAP00000037258 | ENSBTAP00000000596 | Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). Belongs to the PPP phosphatase family. PP-1 subfamily. | 0.856 |
LCMT1 | PPP2CB | ENSBTAP00000037258 | ENSBTAP00000012182 | Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. | 0.856 |
LCMT1 | PPP2R1A | ENSBTAP00000037258 | ENSBTAP00000026449 | Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis. | 0.726 |
LCMT1 | PPP2R1B | ENSBTAP00000037258 | ENSBTAP00000027023 | Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. | Protein phosphatase 2 scaffold subunit Abeta. | 0.767 |
LCMT1 | PPP2R2A | ENSBTAP00000037258 | ENSBTAP00000024373 | Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. | 0.714 |
LCMT1 | PPP2R5D | ENSBTAP00000037258 | ENSBTAP00000007277 | Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | 0.469 |
PPME1 | ABHD17B | ENSBTAP00000039548 | ENSBTAP00000008957 | Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity); Belongs to the AB hydrolase superfamily. | Abhydrolase domain containing 17B. | 0.741 |
PPME1 | CIP2A | ENSBTAP00000039548 | ENSBTAP00000022784 | Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity); Belongs to the AB hydrolase superfamily. | Cell proliferation regulating inhibitor of protein phosphatase 2A. | 0.777 |
PPME1 | LCMT1 | ENSBTAP00000039548 | ENSBTAP00000037258 | Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity); Belongs to the AB hydrolase superfamily. | Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. | 0.924 |
PPME1 | PPP2CA | ENSBTAP00000039548 | ENSBTAP00000000596 | Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity); Belongs to the AB hydrolase superfamily. | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). Belongs to the PPP phosphatase family. PP-1 subfamily. | 0.878 |
PPME1 | PPP2CB | ENSBTAP00000039548 | ENSBTAP00000012182 | Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity); Belongs to the AB hydrolase superfamily. | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. | 0.885 |
PPME1 | PPP2R1A | ENSBTAP00000039548 | ENSBTAP00000026449 | Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity); Belongs to the AB hydrolase superfamily. | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis. | 0.880 |