node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APH1A | APH1B | ENSBTAP00000071445 | ENSBTAP00000058426 | Aph-1 homolog A, gamma-secretase subunit. | Aph-1 homolog B, gamma-secretase subunit. | 0.568 |
APH1A | APP | ENSBTAP00000071445 | ENSBTAP00000060984 | Aph-1 homolog A, gamma-secretase subunit. | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.710 |
APH1A | NCSTN | ENSBTAP00000071445 | ENSBTAP00000068930 | Aph-1 homolog A, gamma-secretase subunit. | Nicastrin. | 0.999 |
APH1A | NOTCH1 | ENSBTAP00000071445 | ENSBTAP00000017746 | Aph-1 homolog A, gamma-secretase subunit. | Notch receptor 1. | 0.851 |
APH1A | PSEN1 | ENSBTAP00000071445 | ENSBTAP00000040765 | Aph-1 homolog A, gamma-secretase subunit. | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] | 0.998 |
APH1A | PSEN2 | ENSBTAP00000071445 | ENSBTAP00000057595 | Aph-1 homolog A, gamma-secretase subunit. | Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...] | 0.994 |
APH1A | PSENEN | ENSBTAP00000071445 | ENSBTAP00000024745 | Aph-1 homolog A, gamma-secretase subunit. | Gamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity. | 0.998 |
APH1B | APH1A | ENSBTAP00000058426 | ENSBTAP00000071445 | Aph-1 homolog B, gamma-secretase subunit. | Aph-1 homolog A, gamma-secretase subunit. | 0.568 |
APH1B | APP | ENSBTAP00000058426 | ENSBTAP00000060984 | Aph-1 homolog B, gamma-secretase subunit. | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.768 |
APH1B | NCSTN | ENSBTAP00000058426 | ENSBTAP00000068930 | Aph-1 homolog B, gamma-secretase subunit. | Nicastrin. | 0.998 |
APH1B | NOTCH1 | ENSBTAP00000058426 | ENSBTAP00000017746 | Aph-1 homolog B, gamma-secretase subunit. | Notch receptor 1. | 0.572 |
APH1B | PSEN1 | ENSBTAP00000058426 | ENSBTAP00000040765 | Aph-1 homolog B, gamma-secretase subunit. | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] | 0.997 |
APH1B | PSEN2 | ENSBTAP00000058426 | ENSBTAP00000057595 | Aph-1 homolog B, gamma-secretase subunit. | Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...] | 0.996 |
APH1B | PSENEN | ENSBTAP00000058426 | ENSBTAP00000024745 | Aph-1 homolog B, gamma-secretase subunit. | Gamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity. | 0.998 |
APP | APH1A | ENSBTAP00000060984 | ENSBTAP00000071445 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Aph-1 homolog A, gamma-secretase subunit. | 0.710 |
APP | APH1B | ENSBTAP00000060984 | ENSBTAP00000058426 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Aph-1 homolog B, gamma-secretase subunit. | 0.768 |
APP | CTNNB1 | ENSBTAP00000060984 | ENSBTAP00000021838 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | 0.579 |
APP | GSK3B | ENSBTAP00000060984 | ENSBTAP00000051604 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.733 |
APP | NCSTN | ENSBTAP00000060984 | ENSBTAP00000068930 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Nicastrin. | 0.966 |
APP | NOTCH1 | ENSBTAP00000060984 | ENSBTAP00000017746 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Notch receptor 1. | 0.538 |