node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANGPT4 | CCM2L | ENSBTAP00000029073 | ENSBTAP00000042050 | Angiopoietin-4; Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis (By similarity). | CCM2 like scaffold protein. | 0.497 |
BPIFA1 | BPIFB1 | ENSBTAP00000069828 | ENSBTAP00000020875 | BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid ho [...] | BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS (By similarity). | 0.948 |
BPIFA1 | CCM2L | ENSBTAP00000069828 | ENSBTAP00000042050 | BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid ho [...] | CCM2 like scaffold protein. | 0.496 |
BPIFA1 | FAM151A | ENSBTAP00000069828 | ENSBTAP00000063442 | BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid ho [...] | Uncharacterized protein. | 0.424 |
BPIFB1 | BPIFA1 | ENSBTAP00000020875 | ENSBTAP00000069828 | BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS (By similarity). | BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid ho [...] | 0.948 |
BPIFB1 | CCM2L | ENSBTAP00000020875 | ENSBTAP00000042050 | BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS (By similarity). | CCM2 like scaffold protein. | 0.530 |
BPIFB1 | FAM151A | ENSBTAP00000020875 | ENSBTAP00000063442 | BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS (By similarity). | Uncharacterized protein. | 0.451 |
CCM2L | ANGPT4 | ENSBTAP00000042050 | ENSBTAP00000029073 | CCM2 like scaffold protein. | Angiopoietin-4; Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis (By similarity). | 0.497 |
CCM2L | BPIFA1 | ENSBTAP00000042050 | ENSBTAP00000069828 | CCM2 like scaffold protein. | BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid ho [...] | 0.496 |
CCM2L | BPIFB1 | ENSBTAP00000042050 | ENSBTAP00000020875 | CCM2 like scaffold protein. | BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS (By similarity). | 0.530 |
CCM2L | FAM151A | ENSBTAP00000042050 | ENSBTAP00000063442 | CCM2 like scaffold protein. | Uncharacterized protein. | 0.484 |
CCM2L | ITGB1BP1 | ENSBTAP00000042050 | ENSBTAP00000017362 | CCM2 like scaffold protein. | Integrin beta-1-binding protein 1; Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling [...] | 0.516 |
CCM2L | KRIT1 | ENSBTAP00000042050 | ENSBTAP00000003566 | CCM2 like scaffold protein. | Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH- dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen an [...] | 0.727 |
CCM2L | MAP3K2 | ENSBTAP00000042050 | ENSBTAP00000005525 | CCM2 like scaffold protein. | Mitogen-activated protein kinase kinase kinase 2. | 0.657 |
CCM2L | MAP3K3 | ENSBTAP00000042050 | ENSBTAP00000058887 | CCM2 like scaffold protein. | Mitogen-activated protein kinase kinase kinase 3. | 0.657 |
CCM2L | PDCD10 | ENSBTAP00000042050 | ENSBTAP00000066778 | CCM2 like scaffold protein. | Programmed cell death 10. | 0.727 |
CCM2L | RASIP1 | ENSBTAP00000042050 | ENSBTAP00000015431 | CCM2 like scaffold protein. | Ras interacting protein 1. | 0.651 |
FAM151A | BPIFA1 | ENSBTAP00000063442 | ENSBTAP00000069828 | Uncharacterized protein. | BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid ho [...] | 0.424 |
FAM151A | BPIFB1 | ENSBTAP00000063442 | ENSBTAP00000020875 | Uncharacterized protein. | BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS (By similarity). | 0.451 |
FAM151A | CCM2L | ENSBTAP00000063442 | ENSBTAP00000042050 | Uncharacterized protein. | CCM2 like scaffold protein. | 0.484 |