Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SPEM1Spermatid maturation protein 1; Required for proper cytoplasm removal during spermatogenesis. (313 aa)    
Predicted Functional Partners:
TNP1
Spermatid nuclear transition protein 1; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
      
 0.872
SPATA16
Spermatogenesis associated 16.
      
 0.739
PRSS37
Probable inactive serine protease 37; Plays a role in male fertility. May have a role in sperm migration or binding to zona-intact eggs. Involved in the activation of the proacrosin/acrosin system; Belongs to the peptidase S1 family.
     
 0.730
CIB4
Calcium and integrin binding family member 4.
    
 
 0.730
DNAH17
Dynein axonemal heavy chain 17.
   
  
 0.726
FAM170A
Family with sequence similarity 170 member A.
   
  
 0.712
TMEM95
Transmembrane protein 95.
      
 0.712
SPATA19
Spermatogenesis-associated protein 19, mitochondrial; May have a role in spermiogenesis.
   
  
 0.704
PRM2
Protamine-2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
      
 0.701
ARRDC5
Arrestin domain-containing protein 5; Belongs to the arrestin family.
   
  
 0.684
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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