Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CA1Carbonic anhydrase 1; Reversible hydration of carbon dioxide. (261 aa)    
Predicted Functional Partners:
CA2
Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide.
  
 
0.774
SLC4A1
Anion exchange protein.
   
 
 0.720
EPB42
Erythrocyte membrane protein band 4.2; Band 4.2 probably plays an important role in the regulation of erythrocyte shape and mechanical properties. The major membrane binding for band 4.2 is the cytoplasmic domain of the erythrocyte anion transporter, band 3 (By similarity); Belongs to the transglutaminase superfamily. Transglutaminase family.
   
  
 0.664
AHSP
Alpha-hemoglobin-stabilizing protein; Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation (By similarity).
   
  
 0.643
ALB
Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The sh [...]
    
 
 0.641
RPF2
Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family.
   
 
 0.579
CA3
Carbonic anhydrase 3; Reversible hydration of carbon dioxide; Belongs to the alpha-carbonic anhydrase family.
  
  
0.538
CA7
Carbonic anhydrase 7; Belongs to the alpha-carbonic anhydrase family.
  
  
0.522
CA13
Carbonic anhydrase 13; Belongs to the alpha-carbonic anhydrase family.
  
  
0.520
CA4
Carbonic anhydrase 4; Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 (By similarity). Belongs to the alpha-carbonic anhydrase family.
  
 
0.514
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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