Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
RMDN2Regulator of microtubule dynamics protein 2. (497 aa)    
Predicted Functional Partners:
RMDN3
Regulator of microtubule dynamics protein 3; Involved in cellular calcium homeostasis regulation (By similarity). May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis (By similarity). Belongs to the RMDN family.
  
 
 
0.940
VAPB
Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.
    
 
 0.834
ENSBTAP00000058824
MSP domain-containing protein.
    
 
 0.788
SLC66A3
Solute carrier family 66 member 3.
      
 0.785
BBOF1
Basal body orientation factor 1.
    
 
 0.705
VAPA
Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking.
    
 
 0.694
ENSBTAP00000067530
MSP domain-containing protein.
    
 
 0.694
MBOAT2
Membrane bound O-acyltransferase domain containing 2; Belongs to the membrane-bound acyltransferase family.
   
 0.674
STARD3NL
STARD3 N-terminal like.
      
 0.647
GPAT2
Glycerol-3-phosphate acyltransferase 2, mitochondrial.
  
 
 0.641
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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