STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ALMS1ALMS1 centrosome and basal body associated protein. (4331 aa)    
Predicted Functional Partners:
PLK1
Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase- promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, C [...]
    
  0.804
CCDC158
Coiled-coil domain containing 158.
    
 
 0.691
CEP295
Centrosomal protein 295.
   
  
 0.681
BBS1
BBS1 domain-containing protein.
    
 
 0.665
USP34
Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family.
   
    0.661
BBS10
Bardet-Biedl syndrome 10.
    
 
 0.654
CMYA5
Cardiomyopathy associated 5.
  
 
 
 0.651
CCDC136
Coiled-coil domain containing 136.
  
 
 
 0.634
ASH1L
ASH1 like histone lysine methyltransferase.
   
 
 0.624
FAM71B
Family with sequence similarity 71 member B.
  
  
 0.623
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.