node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BGLAP | CD44 | ENSBTAP00000047703 | ENSBTAP00000048925 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | CD44 antigen. | 0.667 |
BGLAP | ITGAV | ENSBTAP00000047703 | ENSBTAP00000060618 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Integrin alpha-V heavy chain; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential [...] | 0.405 |
BGLAP | ITGB1 | ENSBTAP00000047703 | ENSBTAP00000052015 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.664 |
BGLAP | MMP3 | ENSBTAP00000047703 | ENSBTAP00000013124 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | ZnMc domain-containing protein. | 0.407 |
BGLAP | SPARC | ENSBTAP00000047703 | ENSBTAP00000065130 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. | 0.966 |
BGLAP | SPP1 | ENSBTAP00000047703 | ENSBTAP00000062863 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. | 0.962 |
CD44 | BGLAP | ENSBTAP00000048925 | ENSBTAP00000047703 | CD44 antigen. | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | 0.667 |
CD44 | ITGA4 | ENSBTAP00000048925 | ENSBTAP00000012194 | CD44 antigen. | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | 0.716 |
CD44 | ITGAV | ENSBTAP00000048925 | ENSBTAP00000060618 | CD44 antigen. | Integrin alpha-V heavy chain; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential [...] | 0.811 |
CD44 | ITGB1 | ENSBTAP00000048925 | ENSBTAP00000052015 | CD44 antigen. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.942 |
CD44 | ITGB3 | ENSBTAP00000048925 | ENSBTAP00000013173 | CD44 antigen. | Integrin beta; Belongs to the integrin beta chain family. | 0.745 |
CD44 | MMP3 | ENSBTAP00000048925 | ENSBTAP00000013124 | CD44 antigen. | ZnMc domain-containing protein. | 0.606 |
CD44 | SPARC | ENSBTAP00000048925 | ENSBTAP00000065130 | CD44 antigen. | SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. | 0.597 |
CD44 | SPP1 | ENSBTAP00000048925 | ENSBTAP00000062863 | CD44 antigen. | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. | 0.999 |
ITGA4 | CD44 | ENSBTAP00000012194 | ENSBTAP00000048925 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | CD44 antigen. | 0.716 |
ITGA4 | ITGA9 | ENSBTAP00000012194 | ENSBTAP00000022042 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Integrin subunit alpha 9; Belongs to the integrin alpha chain family. | 0.568 |
ITGA4 | ITGAV | ENSBTAP00000012194 | ENSBTAP00000060618 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Integrin alpha-V heavy chain; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential [...] | 0.783 |
ITGA4 | ITGB1 | ENSBTAP00000012194 | ENSBTAP00000052015 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.999 |
ITGA4 | ITGB3 | ENSBTAP00000012194 | ENSBTAP00000013173 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Integrin beta; Belongs to the integrin beta chain family. | 0.966 |
ITGA4 | ITGB5 | ENSBTAP00000012194 | ENSBTAP00000018278 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Integrin beta-5; Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand. | 0.896 |