STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
POU1F1Pituitary-specific positive transcription factor 1; Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'. (291 aa)    
Predicted Functional Partners:
PROP1
Homeobox protein prophet of Pit-1; Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.
   
 
 0.894
PRL
Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation.
   
  
 0.810
TSHB
Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism.
   
  
 0.805
PRP3
Placental prolactin-related protein 3; Placental prolactin-related proteins may play a specific role during gestation; Belongs to the somatotropin/prolactin family.
   
  
 0.769
LOC100298767
Growth hormone E4.
   
  
 0.762
PRP8
Prolactin-related protein VIII.
   
  
 0.762
PRP9
Prolactin-related protein IX.
   
  
 0.762
PRP-VII
Growth hormone E5.
   
  
 0.762
PRP14
Prolactin-related protein XIV.
   
  
 0.762
PRP1
Placental prolactin-related protein 1; Placental prolactin-related proteins may play a specific role during gestation.
   
  
 0.762
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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