| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DEPDC5 | FLCN | ENSBTAP00000001707 | ENSBTAP00000010532 | DEP domain containing 5. | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | 0.533 |
| DEPDC5 | LAMTOR1 | ENSBTAP00000001707 | ENSBTAP00000059517 | DEP domain containing 5. | Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulat [...] | 0.823 |
| DEPDC5 | LAMTOR3 | ENSBTAP00000001707 | ENSBTAP00000044998 | DEP domain containing 5. | Ragulator complex protein LAMTOR3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] | 0.825 |
| DEPDC5 | MTOR | ENSBTAP00000001707 | ENSBTAP00000020386 | DEP domain containing 5. | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | 0.673 |
| DEPDC5 | NPRL2 | ENSBTAP00000001707 | ENSBTAP00000065594 | DEP domain containing 5. | GATOR complex protein NPRL2; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway; Belongs to the NPR2 family. | 0.999 |
| DEPDC5 | NPRL3 | ENSBTAP00000001707 | ENSBTAP00000022032 | DEP domain containing 5. | NPR3 like, GATOR1 complex subunit. | 0.999 |
| DEPDC5 | RRAGA | ENSBTAP00000001707 | ENSBTAP00000051093 | DEP domain containing 5. | Ras-related GTP-binding protein A; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. | 0.989 |
| DEPDC5 | RRAGC | ENSBTAP00000001707 | ENSBTAP00000012331 | DEP domain containing 5. | Ras-related GTP binding C. | 0.953 |
| DEPDC5 | RRAGD | ENSBTAP00000001707 | ENSBTAP00000059277 | DEP domain containing 5. | Ras related GTP binding D. | 0.851 |
| FLCN | DEPDC5 | ENSBTAP00000010532 | ENSBTAP00000001707 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | DEP domain containing 5. | 0.533 |
| FLCN | FNIP2 | ENSBTAP00000010532 | ENSBTAP00000070282 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | Folliculin interacting protein 2. | 0.999 |
| FLCN | LAMTOR1 | ENSBTAP00000010532 | ENSBTAP00000059517 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulat [...] | 0.836 |
| FLCN | LAMTOR3 | ENSBTAP00000010532 | ENSBTAP00000044998 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | Ragulator complex protein LAMTOR3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] | 0.843 |
| FLCN | MTOR | ENSBTAP00000010532 | ENSBTAP00000020386 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | 0.554 |
| FLCN | NPRL2 | ENSBTAP00000010532 | ENSBTAP00000065594 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | GATOR complex protein NPRL2; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway; Belongs to the NPR2 family. | 0.873 |
| FLCN | NPRL3 | ENSBTAP00000010532 | ENSBTAP00000022032 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | NPR3 like, GATOR1 complex subunit. | 0.597 |
| FLCN | RRAGA | ENSBTAP00000010532 | ENSBTAP00000051093 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | Ras-related GTP-binding protein A; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. | 0.988 |
| FLCN | RRAGC | ENSBTAP00000010532 | ENSBTAP00000012331 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | Ras-related GTP binding C. | 0.986 |
| FLCN | RRAGD | ENSBTAP00000010532 | ENSBTAP00000059277 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | Ras related GTP binding D. | 0.983 |
| FNIP2 | FLCN | ENSBTAP00000070282 | ENSBTAP00000010532 | Folliculin interacting protein 2. | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | 0.999 |
STRING v12.5 is now available!
