node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANAPC4 | BUB1 | ENSBTAP00000000852 | ENSBTAP00000028226 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. | BUB1 mitotic checkpoint serine/threonine kinase. | 0.854 |
ANAPC4 | BUB1B | ENSBTAP00000000852 | ENSBTAP00000009521 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. | BUB1 mitotic checkpoint serine/threonine kinase B. | 0.990 |
ANAPC4 | BUB3 | ENSBTAP00000000852 | ENSBTAP00000051164 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. | Mitotic checkpoint protein BUB3; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. T [...] | 0.987 |
ANAPC4 | CDC20 | ENSBTAP00000000852 | ENSBTAP00000012945 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. | Cell division cycle 20. | 0.982 |
ANAPC4 | CDC23 | ENSBTAP00000000852 | ENSBTAP00000011540 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. | Cell division cycle protein 23 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity); Belongs to the APC8/CDC23 family. | 0.998 |
ANAPC4 | CDC27 | ENSBTAP00000000852 | ENSBTAP00000057334 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. | Cell division cycle protein 27 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). | 0.997 |
ANAPC4 | MAD1L1 | ENSBTAP00000000852 | ENSBTAP00000060075 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. | Mitotic arrest deficient 1 like 1. | 0.734 |
ANAPC4 | MAD2L1 | ENSBTAP00000000852 | ENSBTAP00000054090 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. | Mitotic arrest deficient 2 like 1. | 0.988 |
BUB1 | ANAPC4 | ENSBTAP00000028226 | ENSBTAP00000000852 | BUB1 mitotic checkpoint serine/threonine kinase. | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. | 0.854 |
BUB1 | BUB1B | ENSBTAP00000028226 | ENSBTAP00000009521 | BUB1 mitotic checkpoint serine/threonine kinase. | BUB1 mitotic checkpoint serine/threonine kinase B. | 0.998 |
BUB1 | BUB3 | ENSBTAP00000028226 | ENSBTAP00000051164 | BUB1 mitotic checkpoint serine/threonine kinase. | Mitotic checkpoint protein BUB3; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. T [...] | 0.999 |
BUB1 | CDC20 | ENSBTAP00000028226 | ENSBTAP00000012945 | BUB1 mitotic checkpoint serine/threonine kinase. | Cell division cycle 20. | 0.999 |
BUB1 | CDC23 | ENSBTAP00000028226 | ENSBTAP00000011540 | BUB1 mitotic checkpoint serine/threonine kinase. | Cell division cycle protein 23 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity); Belongs to the APC8/CDC23 family. | 0.926 |
BUB1 | CDC27 | ENSBTAP00000028226 | ENSBTAP00000057334 | BUB1 mitotic checkpoint serine/threonine kinase. | Cell division cycle protein 27 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). | 0.921 |
BUB1 | CENPE | ENSBTAP00000028226 | ENSBTAP00000011898 | BUB1 mitotic checkpoint serine/threonine kinase. | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.979 |
BUB1 | MAD1L1 | ENSBTAP00000028226 | ENSBTAP00000060075 | BUB1 mitotic checkpoint serine/threonine kinase. | Mitotic arrest deficient 1 like 1. | 0.994 |
BUB1 | MAD2L1 | ENSBTAP00000028226 | ENSBTAP00000054090 | BUB1 mitotic checkpoint serine/threonine kinase. | Mitotic arrest deficient 2 like 1. | 0.995 |
BUB1 | ZNF207 | ENSBTAP00000028226 | ENSBTAP00000068447 | BUB1 mitotic checkpoint serine/threonine kinase. | Zinc finger protein 207. | 0.468 |
BUB1B | ANAPC4 | ENSBTAP00000009521 | ENSBTAP00000000852 | BUB1 mitotic checkpoint serine/threonine kinase B. | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. | 0.990 |
BUB1B | BUB1 | ENSBTAP00000009521 | ENSBTAP00000028226 | BUB1 mitotic checkpoint serine/threonine kinase B. | BUB1 mitotic checkpoint serine/threonine kinase. | 0.998 |