| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APC | AXIN1 | ENSBTAP00000057792 | ENSBTAP00000067751 | APC regulator of WNT signaling pathway. | Axin 1. | 0.999 |
| APC | AXIN2 | ENSBTAP00000057792 | ENSBTAP00000040177 | APC regulator of WNT signaling pathway. | Axin 2. | 0.989 |
| APC | CCND1 | ENSBTAP00000057792 | ENSBTAP00000023277 | APC regulator of WNT signaling pathway. | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | 0.453 |
| APC | CTNNB1 | ENSBTAP00000057792 | ENSBTAP00000021838 | APC regulator of WNT signaling pathway. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | 0.999 |
| APC | DVL2 | ENSBTAP00000057792 | ENSBTAP00000057707 | APC regulator of WNT signaling pathway. | Dishevelled segment polarity protein 2. | 0.981 |
| APC | FRAT1 | ENSBTAP00000057792 | ENSBTAP00000010458 | APC regulator of WNT signaling pathway. | FRAT regulator of WNT signaling pathway 1. | 0.606 |
| APC | FRAT2 | ENSBTAP00000057792 | ENSBTAP00000055602 | APC regulator of WNT signaling pathway. | FRAT regulator of WNT signaling pathway 2. | 0.606 |
| APC | GSK3B | ENSBTAP00000057792 | ENSBTAP00000051604 | APC regulator of WNT signaling pathway. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.998 |
| AXIN1 | APC | ENSBTAP00000067751 | ENSBTAP00000057792 | Axin 1. | APC regulator of WNT signaling pathway. | 0.999 |
| AXIN1 | AXIN2 | ENSBTAP00000067751 | ENSBTAP00000040177 | Axin 1. | Axin 2. | 0.997 |
| AXIN1 | CCND1 | ENSBTAP00000067751 | ENSBTAP00000023277 | Axin 1. | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | 0.798 |
| AXIN1 | CTNNB1 | ENSBTAP00000067751 | ENSBTAP00000021838 | Axin 1. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | 0.999 |
| AXIN1 | DVL2 | ENSBTAP00000067751 | ENSBTAP00000057707 | Axin 1. | Dishevelled segment polarity protein 2. | 0.992 |
| AXIN1 | FRAT1 | ENSBTAP00000067751 | ENSBTAP00000010458 | Axin 1. | FRAT regulator of WNT signaling pathway 1. | 0.744 |
| AXIN1 | FRAT2 | ENSBTAP00000067751 | ENSBTAP00000055602 | Axin 1. | FRAT regulator of WNT signaling pathway 2. | 0.715 |
| AXIN1 | GSK3B | ENSBTAP00000067751 | ENSBTAP00000051604 | Axin 1. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.999 |
| AXIN2 | APC | ENSBTAP00000040177 | ENSBTAP00000057792 | Axin 2. | APC regulator of WNT signaling pathway. | 0.989 |
| AXIN2 | AXIN1 | ENSBTAP00000040177 | ENSBTAP00000067751 | Axin 2. | Axin 1. | 0.997 |
| AXIN2 | CCND1 | ENSBTAP00000040177 | ENSBTAP00000023277 | Axin 2. | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | 0.884 |
| AXIN2 | CTNNB1 | ENSBTAP00000040177 | ENSBTAP00000021838 | Axin 2. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | 0.999 |
