STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
KCNB2Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric an [...] (911 aa)    
Predicted Functional Partners:
KCNAB2
Voltage-gated potassium channel subunit beta-2; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (By similarity). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore- forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (By similarity). Promotes KCNA4 channel closure (By similarit [...]
   
 0.733
KCNAB3
Potassium voltage-gated channel, shaker-related subfamily, beta member 3.
   
 0.714
FAU
Ubiquitin-like protein FUBI.
   
   0.702
ENSBTAP00000061435
40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.
   
   0.702
ENSBTAP00000070171
40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.
   
   0.702
GRXCR2
Glutaredoxin and cysteine rich domain containing 2.
   
  
 0.662
RPL31
60S ribosomal protein L31; Belongs to the eukaryotic ribosomal protein eL31 family.
   
 
 0.656
CSKMT
Citrate synthase lysine methyltransferase.
      
 0.651
RPS24
40S ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS24 family.
   
 
 0.650
RPS17
40S ribosomal protein S17; Belongs to the eukaryotic ribosomal protein eS17 family.
   
 
 0.645
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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