node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GLRX | GPX1 | ENSBTAP00000051774 | ENSBTAP00000061122 | Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Belongs to the glutaredoxin family. | Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. | 0.748 |
GLRX | GPX3 | ENSBTAP00000051774 | ENSBTAP00000053146 | Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Belongs to the glutaredoxin family. | Glutathione peroxidase 3; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. | 0.747 |
GLRX | GPX5 | ENSBTAP00000051774 | ENSBTAP00000015939 | Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Belongs to the glutaredoxin family. | Glutathione peroxidase; Belongs to the glutathione peroxidase family. | 0.747 |
GLRX | GPX7 | ENSBTAP00000051774 | ENSBTAP00000024329 | Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Belongs to the glutaredoxin family. | Glutathione peroxidase 7; Belongs to the glutathione peroxidase family. | 0.750 |
GLRX | GPX8 | ENSBTAP00000051774 | ENSBTAP00000029279 | Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Belongs to the glutaredoxin family. | Probable glutathione peroxidase 8; Belongs to the glutathione peroxidase family. | 0.750 |
GLRX | GSR | ENSBTAP00000051774 | ENSBTAP00000009363 | Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Belongs to the glutaredoxin family. | Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.905 |
GLRX | TXN | ENSBTAP00000051774 | ENSBTAP00000041860 | Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Belongs to the glutaredoxin family. | Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] | 0.919 |
GLRX | TXNDC8 | ENSBTAP00000051774 | ENSBTAP00000013931 | Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Belongs to the glutaredoxin family. | Thioredoxin; Belongs to the thioredoxin family. | 0.911 |
GLRX | TXNRD1 | ENSBTAP00000051774 | ENSBTAP00000018473 | Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Belongs to the glutaredoxin family. | Thioredoxin reductase 1, cytoplasmic. | 0.757 |
GLRX | TXNRD2 | ENSBTAP00000051774 | ENSBTAP00000053158 | Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Belongs to the glutaredoxin family. | Thioredoxin reductase 2, mitochondrial; Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (By similarity). Maintains thioredoxin in a reduced state. May play a role in redox- regulated cell signaling. | 0.776 |
GPX1 | GLRX | ENSBTAP00000061122 | ENSBTAP00000051774 | Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. | Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Belongs to the glutaredoxin family. | 0.748 |
GPX1 | GPX3 | ENSBTAP00000061122 | ENSBTAP00000053146 | Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. | Glutathione peroxidase 3; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. | 0.916 |
GPX1 | GPX7 | ENSBTAP00000061122 | ENSBTAP00000024329 | Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. | Glutathione peroxidase 7; Belongs to the glutathione peroxidase family. | 0.934 |
GPX1 | GPX8 | ENSBTAP00000061122 | ENSBTAP00000029279 | Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. | Probable glutathione peroxidase 8; Belongs to the glutathione peroxidase family. | 0.933 |
GPX1 | GSR | ENSBTAP00000061122 | ENSBTAP00000009363 | Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. | Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.995 |
GPX1 | TXN | ENSBTAP00000061122 | ENSBTAP00000041860 | Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. | Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] | 0.888 |
GPX1 | TXNDC8 | ENSBTAP00000061122 | ENSBTAP00000013931 | Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. | Thioredoxin; Belongs to the thioredoxin family. | 0.869 |
GPX1 | TXNRD1 | ENSBTAP00000061122 | ENSBTAP00000018473 | Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. | Thioredoxin reductase 1, cytoplasmic. | 0.830 |
GPX1 | TXNRD2 | ENSBTAP00000061122 | ENSBTAP00000053158 | Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. | Thioredoxin reductase 2, mitochondrial; Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (By similarity). Maintains thioredoxin in a reduced state. May play a role in redox- regulated cell signaling. | 0.788 |
GPX3 | GLRX | ENSBTAP00000053146 | ENSBTAP00000051774 | Glutathione peroxidase 3; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. | Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Belongs to the glutaredoxin family. | 0.747 |