node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMT | ATIC | ENSBTAP00000002992 | ENSBTAP00000025662 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | 0.979 |
AMT | DHFR | ENSBTAP00000002992 | ENSBTAP00000010103 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2 (By similarity). | 0.971 |
AMT | FTCD | ENSBTAP00000002992 | ENSBTAP00000071351 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Formimidoyltransferase cyclodeaminase. | 0.925 |
AMT | GART | ENSBTAP00000002992 | ENSBTAP00000012108 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Trifunctional purine biosynthetic protein adenosine-3; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | 0.958 |
AMT | MTHFD1L | ENSBTAP00000002992 | ENSBTAP00000052260 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Monofunctional C1-tetrahydrofolate synthase, mitochondrial; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. | 0.973 |
AMT | MTHFD2 | ENSBTAP00000002992 | ENSBTAP00000006419 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. | 0.992 |
AMT | MTHFD2L | ENSBTAP00000002992 | ENSBTAP00000053516 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Uncharacterized protein. | 0.993 |
AMT | MTR | ENSBTAP00000002992 | ENSBTAP00000067894 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.957 |
AMT | SHMT1 | ENSBTAP00000002992 | ENSBTAP00000022732 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. | 0.985 |
AMT | SHMT2 | ENSBTAP00000002992 | ENSBTAP00000038059 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial tran [...] | 0.988 |
ATIC | AMT | ENSBTAP00000025662 | ENSBTAP00000002992 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | 0.979 |
ATIC | DHFR | ENSBTAP00000025662 | ENSBTAP00000010103 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2 (By similarity). | 0.979 |
ATIC | FTCD | ENSBTAP00000025662 | ENSBTAP00000071351 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Formimidoyltransferase cyclodeaminase. | 0.932 |
ATIC | GART | ENSBTAP00000025662 | ENSBTAP00000012108 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Trifunctional purine biosynthetic protein adenosine-3; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | 0.999 |
ATIC | MTHFD1L | ENSBTAP00000025662 | ENSBTAP00000052260 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Monofunctional C1-tetrahydrofolate synthase, mitochondrial; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. | 0.990 |
ATIC | MTHFD2 | ENSBTAP00000025662 | ENSBTAP00000006419 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. | 0.987 |
ATIC | MTHFD2L | ENSBTAP00000025662 | ENSBTAP00000053516 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Uncharacterized protein. | 0.976 |
ATIC | MTR | ENSBTAP00000025662 | ENSBTAP00000067894 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.940 |
ATIC | SHMT1 | ENSBTAP00000025662 | ENSBTAP00000022732 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. | 0.993 |
ATIC | SHMT2 | ENSBTAP00000025662 | ENSBTAP00000038059 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial tran [...] | 0.992 |