node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CACNA2D1 | CACNA2D2 | ENSBTAP00000027409 | ENSBTAP00000042974 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | Calcium voltage-gated channel auxiliary subunit alpha2delta 2. | 0.742 |
CACNA2D1 | CACNB2 | ENSBTAP00000027409 | ENSBTAP00000069538 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. | 0.978 |
CACNA2D1 | CACNB3 | ENSBTAP00000027409 | ENSBTAP00000062215 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | Voltage-dependent L-type calcium channel subunit beta-3; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation. Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). | 0.927 |
CACNA2D1 | CACNB4 | ENSBTAP00000027409 | ENSBTAP00000002971 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | Calcium voltage-gated channel auxiliary subunit beta 4. | 0.922 |
CACNA2D1 | CACNG1 | ENSBTAP00000027409 | ENSBTAP00000009930 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. | 0.977 |
CACNA2D1 | SCN1B | ENSBTAP00000027409 | ENSBTAP00000004980 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | 0.531 |
CACNA2D1 | SCN2B | ENSBTAP00000027409 | ENSBTAP00000073533 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | Uncharacterized protein. | 0.427 |
CACNA2D1 | SCN3B | ENSBTAP00000027409 | ENSBTAP00000066197 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | Sodium channel subunit beta-3; Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity). | 0.560 |
CACNA2D1 | SCN4B | ENSBTAP00000027409 | ENSBTAP00000017826 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | Sodium channel subunit beta-4; Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom (By similarity). | 0.466 |
CACNA2D1 | SCN8A | ENSBTAP00000027409 | ENSBTAP00000053165 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.814 |
CACNA2D2 | CACNA2D1 | ENSBTAP00000042974 | ENSBTAP00000027409 | Calcium voltage-gated channel auxiliary subunit alpha2delta 2. | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | 0.742 |
CACNA2D2 | CACNB2 | ENSBTAP00000042974 | ENSBTAP00000069538 | Calcium voltage-gated channel auxiliary subunit alpha2delta 2. | Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. | 0.917 |
CACNA2D2 | CACNB3 | ENSBTAP00000042974 | ENSBTAP00000062215 | Calcium voltage-gated channel auxiliary subunit alpha2delta 2. | Voltage-dependent L-type calcium channel subunit beta-3; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation. Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). | 0.918 |
CACNA2D2 | CACNB4 | ENSBTAP00000042974 | ENSBTAP00000002971 | Calcium voltage-gated channel auxiliary subunit alpha2delta 2. | Calcium voltage-gated channel auxiliary subunit beta 4. | 0.930 |
CACNA2D2 | CACNG1 | ENSBTAP00000042974 | ENSBTAP00000009930 | Calcium voltage-gated channel auxiliary subunit alpha2delta 2. | Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. | 0.941 |
CACNA2D2 | SCN2B | ENSBTAP00000042974 | ENSBTAP00000073533 | Calcium voltage-gated channel auxiliary subunit alpha2delta 2. | Uncharacterized protein. | 0.432 |
CACNA2D2 | SCN4B | ENSBTAP00000042974 | ENSBTAP00000017826 | Calcium voltage-gated channel auxiliary subunit alpha2delta 2. | Sodium channel subunit beta-4; Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom (By similarity). | 0.565 |
CACNA2D2 | SCN8A | ENSBTAP00000042974 | ENSBTAP00000053165 | Calcium voltage-gated channel auxiliary subunit alpha2delta 2. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.795 |
CACNB2 | CACNA2D1 | ENSBTAP00000069538 | ENSBTAP00000027409 | Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | 0.978 |
CACNB2 | CACNA2D2 | ENSBTAP00000069538 | ENSBTAP00000042974 | Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. | Calcium voltage-gated channel auxiliary subunit alpha2delta 2. | 0.917 |