STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KCNIP4Kv channel-interacting protein 4; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents (By similarity); Belongs to the recoverin family. (250 aa)    
Predicted Functional Partners:
DPP6
Dipeptidyl aminopeptidase-like protein 6; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity. Belongs to the peptidase S9B family.
   
 
 0.778
KCND1
Potassium voltage-gated channel subfamily D member 1; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits (By similarity); Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.1/KCND1 sub-subfamily.
    
 0.768
KCND3
Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family.
    
 0.768
KCND2
Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family.
    
 0.768
DPP10
Dipeptidyl peptidase like 10; Belongs to the peptidase S9B family.
   
 
 0.699
VSTM5
V-set and transmembrane domain containing 5.
      
 0.694
KCNIP1
Potassium voltage-gated channel interacting protein 1.
  
 
0.692
CCSER1
Serine-rich coiled-coil domain-containing protein 1; Belongs to the CCSER family.
      
 0.687
GALNT18
Polypeptide N-acetylgalactosaminyltransferase.
      
 0.627
LCORL
Ligand dependent nuclear receptor corepressor like.
      
 0.625
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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