STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ARHGEF40Rho guanine nucleotide exchange factor 40. (1520 aa)    
Predicted Functional Partners:
ARHGEF17
Rho guanine nucleotide exchange factor 17.
   
  
 0.752
PLEKHG7
Pleckstrin homology and RhoGEF domain containing G7.
      
 0.689
ARHGAP42
Rho GTPase activating protein 42.
      
 0.684
KLHL32
Kelch like family member 32.
      
 0.655
FARP1
FERM, ARH/RhoGEF and pleckstrin domain protein 1.
      
 0.652
ARHGEF33
Rho guanine nucleotide exchange factor 33.
      
 0.626
ARHGAP44
Rho GTPase activating protein 44.
      
 0.597
DLC1
Rho GTPase-activating protein 7; Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality (By similarity).
      
 0.595
ARHGEF37
Rho guanine nucleotide exchange factor 37.
      
 0.594
DENND4B
DENN domain containing 4B.
   
  
 0.591
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.