STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KCPKielin cysteine rich BMP regulator. (1596 aa)    
Predicted Functional Partners:
FNIP1
Folliculin interacting protein 1.
   
 
 0.806
TTYH2
Protein tweety homolog; Probable chloride channel; Belongs to the tweety family.
   
  
 0.737
CNNM1
Cyclin and CBS domain divalent metal cation transport mediator 1.
      
 0.676
LRRC8A
Leucine rich repeat containing 8 family, member A.
    
 
 0.638
TTYH3
Protein tweety homolog; Probable chloride channel; Belongs to the tweety family.
      
 0.625
TTYH1
Protein tweety homolog 1; Probable chloride channel. May be involved in cell adhesion (By similarity); Belongs to the tweety family.
      
 0.589
LRRC8C
Volume-regulated anion channel subunit LRRC8C; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.
    
 
 0.584
TMEM205
Transmembrane protein 205.
      
 0.575
FLYWCH1
FLYWCH-type zinc finger 1.
    
 
 0.567
RFTN2
Raftlin family member 2.
      
 0.483
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.