node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHD4 | EGR2 | ENSBTAP00000019612 | ENSBTAP00000055288 | Chromodomain helicase DNA binding protein 4. | Early growth response 2. | 0.842 |
CHD4 | EP300 | ENSBTAP00000019612 | ENSBTAP00000021556 | Chromodomain helicase DNA binding protein 4. | E1A binding protein p300. | 0.822 |
CHD4 | NAB2 | ENSBTAP00000019612 | ENSBTAP00000008295 | Chromodomain helicase DNA binding protein 4. | NGFI-A binding protein 2 (EGR1 binding protein 2). | 0.912 |
CREBBP | EGR1 | ENSBTAP00000005092 | ENSBTAP00000013284 | CREB binding protein. | Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps pre [...] | 0.577 |
CREBBP | EGR2 | ENSBTAP00000005092 | ENSBTAP00000055288 | CREB binding protein. | Early growth response 2. | 0.918 |
CREBBP | EGR3 | ENSBTAP00000005092 | ENSBTAP00000059244 | CREB binding protein. | Early growth response 3. | 0.938 |
CREBBP | EP300 | ENSBTAP00000005092 | ENSBTAP00000021556 | CREB binding protein. | E1A binding protein p300. | 0.997 |
CREBBP | FOS | ENSBTAP00000005092 | ENSBTAP00000005660 | CREB binding protein. | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] | 0.826 |
EGR1 | CREBBP | ENSBTAP00000013284 | ENSBTAP00000005092 | Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps pre [...] | CREB binding protein. | 0.577 |
EGR1 | EGR2 | ENSBTAP00000013284 | ENSBTAP00000055288 | Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps pre [...] | Early growth response 2. | 0.862 |
EGR1 | EGR3 | ENSBTAP00000013284 | ENSBTAP00000059244 | Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps pre [...] | Early growth response 3. | 0.589 |
EGR1 | EP300 | ENSBTAP00000013284 | ENSBTAP00000021556 | Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps pre [...] | E1A binding protein p300. | 0.747 |
EGR1 | FOS | ENSBTAP00000013284 | ENSBTAP00000005660 | Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps pre [...] | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] | 0.977 |
EGR1 | FOSB | ENSBTAP00000013284 | ENSBTAP00000010762 | Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps pre [...] | FosB proto-oncogene, AP-1 transcription factor subunit. | 0.936 |
EGR1 | NAB1 | ENSBTAP00000013284 | ENSBTAP00000000331 | Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps pre [...] | NGFI-A binding protein 1. | 0.867 |
EGR1 | NAB2 | ENSBTAP00000013284 | ENSBTAP00000008295 | Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps pre [...] | NGFI-A binding protein 2 (EGR1 binding protein 2). | 0.875 |
EGR2 | CHD4 | ENSBTAP00000055288 | ENSBTAP00000019612 | Early growth response 2. | Chromodomain helicase DNA binding protein 4. | 0.842 |
EGR2 | CREBBP | ENSBTAP00000055288 | ENSBTAP00000005092 | Early growth response 2. | CREB binding protein. | 0.918 |
EGR2 | EGR1 | ENSBTAP00000055288 | ENSBTAP00000013284 | Early growth response 2. | Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps pre [...] | 0.862 |
EGR2 | EGR3 | ENSBTAP00000055288 | ENSBTAP00000059244 | Early growth response 2. | Early growth response 3. | 0.972 |