| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AOX4 | MOCOS | ENSBTAP00000048031 | ENSBTAP00000055724 | Aldehyde oxidase 4. | Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily. | 0.791 |
| BHMT2 | MOCOS | ENSBTAP00000045884 | ENSBTAP00000055724 | Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. | Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily. | 0.847 |
| FXN | ISCU | ENSBTAP00000001725 | ENSBTAP00000015648 | Frataxin intermediate form; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity). | Iron-sulfur cluster scaffold homolog (E. coli); Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | 0.997 |
| FXN | LOC533308 | ENSBTAP00000001725 | ENSBTAP00000065498 | Frataxin intermediate form; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity). | NifU_N domain-containing protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | 0.877 |
| FXN | MOCOS | ENSBTAP00000001725 | ENSBTAP00000055724 | Frataxin intermediate form; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity). | Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily. | 0.807 |
| FXN | NFS1 | ENSBTAP00000001725 | ENSBTAP00000009149 | Frataxin intermediate form; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity). | NFS1 protein. | 0.999 |
| FXN | NFU1 | ENSBTAP00000001725 | ENSBTAP00000072777 | Frataxin intermediate form; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity). | NFU1 iron-sulfur cluster scaffold. | 0.859 |
| FXN | SCLY | ENSBTAP00000001725 | ENSBTAP00000013719 | Frataxin intermediate form; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity). | Selenocysteine lyase; Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium. | 0.969 |
| ISCU | FXN | ENSBTAP00000015648 | ENSBTAP00000001725 | Iron-sulfur cluster scaffold homolog (E. coli); Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Frataxin intermediate form; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity). | 0.997 |
| ISCU | MOCOS | ENSBTAP00000015648 | ENSBTAP00000055724 | Iron-sulfur cluster scaffold homolog (E. coli); Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily. | 0.994 |
| ISCU | NFS1 | ENSBTAP00000015648 | ENSBTAP00000009149 | Iron-sulfur cluster scaffold homolog (E. coli); Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | NFS1 protein. | 0.999 |
| ISCU | NFU1 | ENSBTAP00000015648 | ENSBTAP00000072777 | Iron-sulfur cluster scaffold homolog (E. coli); Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | NFU1 iron-sulfur cluster scaffold. | 0.925 |
| ISCU | SCLY | ENSBTAP00000015648 | ENSBTAP00000013719 | Iron-sulfur cluster scaffold homolog (E. coli); Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Selenocysteine lyase; Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium. | 0.976 |
| ISCU | TST | ENSBTAP00000015648 | ENSBTAP00000040894 | Iron-sulfur cluster scaffold homolog (E. coli); Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Thiosulfate sulfurtransferase; Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA (By similarity). Formation of iron- sulfur complexes and cyanide detoxification. Binds molecular oxygen and sulfur. | 0.442 |
| LOC533308 | FXN | ENSBTAP00000065498 | ENSBTAP00000001725 | NifU_N domain-containing protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Frataxin intermediate form; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity). | 0.877 |
| LOC533308 | MOCOS | ENSBTAP00000065498 | ENSBTAP00000055724 | NifU_N domain-containing protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily. | 0.994 |
| LOC533308 | NFS1 | ENSBTAP00000065498 | ENSBTAP00000009149 | NifU_N domain-containing protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | NFS1 protein. | 0.992 |
| LOC533308 | NFU1 | ENSBTAP00000065498 | ENSBTAP00000072777 | NifU_N domain-containing protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | NFU1 iron-sulfur cluster scaffold. | 0.707 |
| LOC533308 | SCLY | ENSBTAP00000065498 | ENSBTAP00000013719 | NifU_N domain-containing protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Selenocysteine lyase; Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium. | 0.975 |
| MOCOS | AOX4 | ENSBTAP00000055724 | ENSBTAP00000048031 | Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily. | Aldehyde oxidase 4. | 0.791 |
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