node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FANCA | FANCC | ENSBTAP00000002478 | ENSBTAP00000022853 | FA complementation group A. | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (By similarity). | 0.999 |
FANCA | FANCD2 | ENSBTAP00000002478 | ENSBTAP00000013299 | FA complementation group A. | FA complementation group D2. | 0.998 |
FANCA | FANCE | ENSBTAP00000002478 | ENSBTAP00000038717 | FA complementation group A. | FA complementation group E. | 0.999 |
FANCA | FANCF | ENSBTAP00000002478 | ENSBTAP00000009509 | FA complementation group A. | FA complementation group F. | 0.999 |
FANCA | FANCG | ENSBTAP00000002478 | ENSBTAP00000049770 | FA complementation group A. | FA complementation group G. | 0.999 |
FANCA | FANCI | ENSBTAP00000002478 | ENSBTAP00000011991 | FA complementation group A. | FA complementation group I. | 0.998 |
FANCA | FANCL | ENSBTAP00000002478 | ENSBTAP00000007713 | FA complementation group A. | Fanconi anemia, complementation group L. | 0.999 |
FANCA | HES1 | ENSBTAP00000002478 | ENSBTAP00000000742 | FA complementation group A. | Transcription factor HES-1; Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'- CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity). | 0.935 |
FANCC | FANCA | ENSBTAP00000022853 | ENSBTAP00000002478 | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (By similarity). | FA complementation group A. | 0.999 |
FANCC | FANCD2 | ENSBTAP00000022853 | ENSBTAP00000013299 | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (By similarity). | FA complementation group D2. | 0.998 |
FANCC | FANCE | ENSBTAP00000022853 | ENSBTAP00000038717 | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (By similarity). | FA complementation group E. | 0.999 |
FANCC | FANCF | ENSBTAP00000022853 | ENSBTAP00000009509 | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (By similarity). | FA complementation group F. | 0.999 |
FANCC | FANCG | ENSBTAP00000022853 | ENSBTAP00000049770 | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (By similarity). | FA complementation group G. | 0.999 |
FANCC | FANCI | ENSBTAP00000022853 | ENSBTAP00000011991 | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (By similarity). | FA complementation group I. | 0.996 |
FANCC | FANCL | ENSBTAP00000022853 | ENSBTAP00000007713 | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (By similarity). | Fanconi anemia, complementation group L. | 0.999 |
FANCC | HES1 | ENSBTAP00000022853 | ENSBTAP00000000742 | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (By similarity). | Transcription factor HES-1; Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'- CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity). | 0.932 |
FANCD2 | FANCA | ENSBTAP00000013299 | ENSBTAP00000002478 | FA complementation group D2. | FA complementation group A. | 0.998 |
FANCD2 | FANCC | ENSBTAP00000013299 | ENSBTAP00000022853 | FA complementation group D2. | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (By similarity). | 0.998 |
FANCD2 | FANCE | ENSBTAP00000013299 | ENSBTAP00000038717 | FA complementation group D2. | FA complementation group E. | 0.992 |
FANCD2 | FANCF | ENSBTAP00000013299 | ENSBTAP00000009509 | FA complementation group D2. | FA complementation group F. | 0.994 |