| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APBB1 | APBB2 | ENSBTAP00000073951 | ENSBTAP00000039437 | Amyloid beta precursor protein binding family B member 1. | Amyloid beta precursor protein binding family B member 2. | 0.884 |
| APBB1 | APLP2 | ENSBTAP00000073951 | ENSBTAP00000056649 | Amyloid beta precursor protein binding family B member 1. | Amyloid beta precursor like protein 2. | 0.939 |
| APBB1 | NAE1 | ENSBTAP00000073951 | ENSBTAP00000013367 | Amyloid beta precursor protein binding family B member 1. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.531 |
| APBB1 | PTI | ENSBTAP00000073951 | ENSBTAP00000056883 | Amyloid beta precursor protein binding family B member 1. | Pancreatic trypsin inhibitor; Inhibits trypsin, kallikrein, chymotrypsin, and plasmin. | 0.967 |
| APBB2 | APBB1 | ENSBTAP00000039437 | ENSBTAP00000073951 | Amyloid beta precursor protein binding family B member 2. | Amyloid beta precursor protein binding family B member 1. | 0.884 |
| APBB2 | APLP2 | ENSBTAP00000039437 | ENSBTAP00000056649 | Amyloid beta precursor protein binding family B member 2. | Amyloid beta precursor like protein 2. | 0.914 |
| APBB2 | PTI | ENSBTAP00000039437 | ENSBTAP00000056883 | Amyloid beta precursor protein binding family B member 2. | Pancreatic trypsin inhibitor; Inhibits trypsin, kallikrein, chymotrypsin, and plasmin. | 0.928 |
| APBB3 | APLP2 | ENSBTAP00000040787 | ENSBTAP00000056649 | Amyloid beta precursor protein binding family B member 3. | Amyloid beta precursor like protein 2. | 0.846 |
| APBB3 | PTI | ENSBTAP00000040787 | ENSBTAP00000056883 | Amyloid beta precursor protein binding family B member 3. | Pancreatic trypsin inhibitor; Inhibits trypsin, kallikrein, chymotrypsin, and plasmin. | 0.908 |
| APLP2 | APBB1 | ENSBTAP00000056649 | ENSBTAP00000073951 | Amyloid beta precursor like protein 2. | Amyloid beta precursor protein binding family B member 1. | 0.939 |
| APLP2 | APBB2 | ENSBTAP00000056649 | ENSBTAP00000039437 | Amyloid beta precursor like protein 2. | Amyloid beta precursor protein binding family B member 2. | 0.914 |
| APLP2 | APBB3 | ENSBTAP00000056649 | ENSBTAP00000040787 | Amyloid beta precursor like protein 2. | Amyloid beta precursor protein binding family B member 3. | 0.846 |
| APLP2 | APOE | ENSBTAP00000056649 | ENSBTAP00000013354 | Amyloid beta precursor like protein 2. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.738 |
| APLP2 | GAPDH | ENSBTAP00000056649 | ENSBTAP00000062798 | Amyloid beta precursor like protein 2. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | 0.474 |
| APLP2 | LOC780933 | ENSBTAP00000056649 | ENSBTAP00000004737 | Amyloid beta precursor like protein 2. | Alpha-trypsin chain 1. | 0.611 |
| APLP2 | NAE1 | ENSBTAP00000056649 | ENSBTAP00000013367 | Amyloid beta precursor like protein 2. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.812 |
| APLP2 | PSEN1 | ENSBTAP00000056649 | ENSBTAP00000040765 | Amyloid beta precursor like protein 2. | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] | 0.746 |
| APLP2 | PTI | ENSBTAP00000056649 | ENSBTAP00000056883 | Amyloid beta precursor like protein 2. | Pancreatic trypsin inhibitor; Inhibits trypsin, kallikrein, chymotrypsin, and plasmin. | 0.927 |
| APOE | APLP2 | ENSBTAP00000013354 | ENSBTAP00000056649 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | Amyloid beta precursor like protein 2. | 0.738 |
| APOE | CASP3 | ENSBTAP00000013354 | ENSBTAP00000021099 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | 0.707 |
