STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SHISA5Protein shisa-5; Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis; Belongs to the shisa family. (216 aa)    
Predicted Functional Partners:
LZTS1
Leucine zipper tumor suppressor 1.
    
 
 0.541
PLPPR5
Phospholipid phosphatase related 5.
    
 
 0.532
NBR1
NBR1 autophagy cargo receptor.
      
 0.514
FAM20C
FAM20C golgi associated secretory pathway kinase.
    
 0.510
EI24
Etoposide-induced protein 2.4 homolog.
      
 0.504
PIDD1
P53-induced death domain protein 1.
    
 
 0.503
PLPPR4
Phospholipid phosphatase related 4.
    
 
 0.499
LGALS8
Galectin.
      
 0.486
FANCC
Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (By similarity).
      
 0.483
USP19
Ubiquitin specific peptidase 19.
  
 
 
 0.472
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.