STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TFECTranscription factor EC; Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter. Collaborates with MITF in target gene activation. Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence. Binds to mu E3 DNA sequence of the imm [...] (350 aa)    
Predicted Functional Partners:
GPNMB
Glycoprotein (Transmembrane) nmb.
   
  
 0.569
PRCC
Papillary renal cell carcinoma (Translocation-associated).
   
  
 0.561
OSTM1
Osteoclastogenesis associated transmembrane protein 1.
      
 0.512
NFKBID
NFKB inhibitor delta.
      
 0.469
WDR49
WD repeat domain 49.
      
 0.469
RGS13
Regulator of G protein signaling 13.
   
  
 0.457
SASH1
SAM and SH3 domain containing 1.
      
 0.452
CSF2RA-2
Fibronectin type-III domain-containing protein.
   
  
 0.448
MAFB
MAF bZIP transcription factor B.
    
 
 0.442
MCOLN1
Mucolipin 1.
      
 0.441
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.