STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FAM3CProtein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition (By similarity); Belongs to the FAM3 family. (227 aa)    
Predicted Functional Partners:
PDCD1
Programmed cell death 1.
    
 
 0.742
CPED1
Cadherin like and PC-esterase domain containing 1.
      
 0.727
CXADR
Coxsackievirus and adenovirus receptor homolog; Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induc [...]
      
 0.600
SORL1
Sortilin related receptor 1.
      
 0.598
CKLF
Chemokine like factor.
      
 0.584
TIGIT
T cell immunoreceptor with Ig and ITIM domains.
      
 0.548
KLRB1
Killer cell lectin like receptor B1.
      
 0.544
LAMP1
Lysosome-associated membrane glycoprotein 1; Belongs to the LAMP family.
    
 
 0.543
TMEM126A
Transmembrane protein 126A.
      
 0.501
TM9SF3
Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
   
  
 0.499
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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