node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYB5A | CYB5R3 | ENSBTAP00000067864 | ENSBTAP00000060914 | Cytochrome b5; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. | NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | 0.977 |
CYB5A | FDXR | ENSBTAP00000067864 | ENSBTAP00000056258 | Cytochrome b5; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. | NADPH:adrenodoxin oxidoreductase, mitochondrial; Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C- 27 hydroxylation in the liver; Belongs to the ferredoxin--NADP reductase type 1 family. | 0.692 |
CYB5A | LOC537017 | ENSBTAP00000067864 | ENSBTAP00000073225 | Cytochrome b5; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. | Rieske domain-containing protein. | 0.400 |
CYB5A | POR | ENSBTAP00000067864 | ENSBTAP00000066469 | Cytochrome b5; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. | NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the N-terminal section; belongs to the flavodoxin family. | 0.939 |
CYB5A | SUOX | ENSBTAP00000067864 | ENSBTAP00000008101 | Cytochrome b5; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. | Sulfite oxidase. | 0.532 |
CYB5B | CYB5R3 | ENSBTAP00000070811 | ENSBTAP00000060914 | Cytochrome b5 type B; Belongs to the cytochrome b5 family. | NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | 0.976 |
CYB5B | FDXR | ENSBTAP00000070811 | ENSBTAP00000056258 | Cytochrome b5 type B; Belongs to the cytochrome b5 family. | NADPH:adrenodoxin oxidoreductase, mitochondrial; Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C- 27 hydroxylation in the liver; Belongs to the ferredoxin--NADP reductase type 1 family. | 0.717 |
CYB5B | LOC537017 | ENSBTAP00000070811 | ENSBTAP00000073225 | Cytochrome b5 type B; Belongs to the cytochrome b5 family. | Rieske domain-containing protein. | 0.400 |
CYB5B | MTARC2 | ENSBTAP00000070811 | ENSBTAP00000008440 | Cytochrome b5 type B; Belongs to the cytochrome b5 family. | Mitochondrial amidoxime reducing component 2; Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transf [...] | 0.675 |
CYB5B | POR | ENSBTAP00000070811 | ENSBTAP00000066469 | Cytochrome b5 type B; Belongs to the cytochrome b5 family. | NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the N-terminal section; belongs to the flavodoxin family. | 0.940 |
CYB5B | SUOX | ENSBTAP00000070811 | ENSBTAP00000008101 | Cytochrome b5 type B; Belongs to the cytochrome b5 family. | Sulfite oxidase. | 0.531 |
CYB5R3 | CYB5A | ENSBTAP00000060914 | ENSBTAP00000067864 | NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | Cytochrome b5; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. | 0.977 |
CYB5R3 | CYB5B | ENSBTAP00000060914 | ENSBTAP00000070811 | NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | Cytochrome b5 type B; Belongs to the cytochrome b5 family. | 0.976 |
CYB5R3 | DHODH | ENSBTAP00000060914 | ENSBTAP00000026495 | NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.931 |
CYB5R3 | DPYD | ENSBTAP00000060914 | ENSBTAP00000007139 | NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. | 0.908 |
CYB5R3 | FDXR | ENSBTAP00000060914 | ENSBTAP00000056258 | NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | NADPH:adrenodoxin oxidoreductase, mitochondrial; Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C- 27 hydroxylation in the liver; Belongs to the ferredoxin--NADP reductase type 1 family. | 0.745 |
CYB5R3 | LOC537017 | ENSBTAP00000060914 | ENSBTAP00000073225 | NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | Rieske domain-containing protein. | 0.905 |
CYB5R3 | MTARC2 | ENSBTAP00000060914 | ENSBTAP00000008440 | NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | Mitochondrial amidoxime reducing component 2; Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transf [...] | 0.697 |
CYB5R3 | POR | ENSBTAP00000060914 | ENSBTAP00000066469 | NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the N-terminal section; belongs to the flavodoxin family. | 0.764 |
CYB5R3 | SUOX | ENSBTAP00000060914 | ENSBTAP00000008101 | NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | Sulfite oxidase. | 0.938 |