| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD4 | CD44 | ENSBTAP00000037566 | ENSBTAP00000048925 | CD4 molecule. | CD44 antigen. | 0.941 |
| CD4 | FOXP3 | ENSBTAP00000037566 | ENSBTAP00000064761 | CD4 molecule. | Forkhead box P3. | 0.957 |
| CD4 | GATA3 | ENSBTAP00000037566 | ENSBTAP00000068033 | CD4 molecule. | Trans-acting T-cell-specific transcription factor GATA-3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses (By similarity). | 0.841 |
| CD4 | IFNG | ENSBTAP00000037566 | ENSBTAP00000016634 | CD4 molecule. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.965 |
| CD4 | IL10 | ENSBTAP00000037566 | ENSBTAP00000059310 | CD4 molecule. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.953 |
| CD4 | IL2 | ENSBTAP00000037566 | ENSBTAP00000027819 | CD4 molecule. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | 0.961 |
| CD4 | IL2RA | ENSBTAP00000037566 | ENSBTAP00000051522 | CD4 molecule. | Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. | 0.867 |
| CD4 | RORC | ENSBTAP00000037566 | ENSBTAP00000070415 | CD4 molecule. | RAR related orphan receptor C. | 0.743 |
| CD4 | RUNX1 | ENSBTAP00000037566 | ENSBTAP00000006224 | CD4 molecule. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.534 |
| CD4 | STAT3 | ENSBTAP00000037566 | ENSBTAP00000028687 | CD4 molecule. | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] | 0.852 |
| CD44 | CD4 | ENSBTAP00000048925 | ENSBTAP00000037566 | CD44 antigen. | CD4 molecule. | 0.941 |
| CD44 | FOXP3 | ENSBTAP00000048925 | ENSBTAP00000064761 | CD44 antigen. | Forkhead box P3. | 0.932 |
| CD44 | GATA3 | ENSBTAP00000048925 | ENSBTAP00000068033 | CD44 antigen. | Trans-acting T-cell-specific transcription factor GATA-3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses (By similarity). | 0.672 |
| CD44 | IFNG | ENSBTAP00000048925 | ENSBTAP00000016634 | CD44 antigen. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.877 |
| CD44 | IL10 | ENSBTAP00000048925 | ENSBTAP00000059310 | CD44 antigen. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.864 |
| CD44 | IL2 | ENSBTAP00000048925 | ENSBTAP00000027819 | CD44 antigen. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | 0.788 |
| CD44 | IL2RA | ENSBTAP00000048925 | ENSBTAP00000051522 | CD44 antigen. | Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. | 0.716 |
| CD44 | RORC | ENSBTAP00000048925 | ENSBTAP00000070415 | CD44 antigen. | RAR related orphan receptor C. | 0.420 |
| CD44 | RUNX1 | ENSBTAP00000048925 | ENSBTAP00000006224 | CD44 antigen. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.577 |
| CD44 | STAT3 | ENSBTAP00000048925 | ENSBTAP00000028687 | CD44 antigen. | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] | 0.778 |
