| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APBB1 | ATM | ENSBTAP00000073951 | ENSBTAP00000039884 | Amyloid beta precursor protein binding family B member 1. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.557 |
| APBB1 | KAT5 | ENSBTAP00000073951 | ENSBTAP00000070633 | Amyloid beta precursor protein binding family B member 1. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.983 |
| ATM | APBB1 | ENSBTAP00000039884 | ENSBTAP00000073951 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Amyloid beta precursor protein binding family B member 1. | 0.557 |
| ATM | KAT5 | ENSBTAP00000039884 | ENSBTAP00000070633 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.987 |
| ATM | TP53 | ENSBTAP00000039884 | ENSBTAP00000001420 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.999 |
| ATM | TRRAP | ENSBTAP00000039884 | ENSBTAP00000009365 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. | 0.610 |
| DMAP1 | EP400 | ENSBTAP00000007766 | ENSBTAP00000027216 | DNA methyltransferase 1 associated protein 1. | E1A binding protein p400. | 0.992 |
| DMAP1 | KAT5 | ENSBTAP00000007766 | ENSBTAP00000070633 | DNA methyltransferase 1 associated protein 1. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.979 |
| DMAP1 | MEAF6 | ENSBTAP00000007766 | ENSBTAP00000052635 | DNA methyltransferase 1 associated protein 1. | Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vi [...] | 0.991 |
| DMAP1 | RUVBL1 | ENSBTAP00000007766 | ENSBTAP00000027964 | DNA methyltransferase 1 associated protein 1. | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | 0.998 |
| DMAP1 | RUVBL2 | ENSBTAP00000007766 | ENSBTAP00000031853 | DNA methyltransferase 1 associated protein 1. | RuvB-like 2; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with oth [...] | 0.998 |
| DMAP1 | TRRAP | ENSBTAP00000007766 | ENSBTAP00000009365 | DNA methyltransferase 1 associated protein 1. | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. | 0.957 |
| DMAP1 | VPS72 | ENSBTAP00000007766 | ENSBTAP00000024063 | DNA methyltransferase 1 associated protein 1. | Vacuolar protein sorting-associated protein 72 homolog; Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. | 0.980 |
| EP400 | DMAP1 | ENSBTAP00000027216 | ENSBTAP00000007766 | E1A binding protein p400. | DNA methyltransferase 1 associated protein 1. | 0.992 |
| EP400 | KAT5 | ENSBTAP00000027216 | ENSBTAP00000070633 | E1A binding protein p400. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.986 |
| EP400 | MEAF6 | ENSBTAP00000027216 | ENSBTAP00000052635 | E1A binding protein p400. | Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vi [...] | 0.996 |
| EP400 | RUVBL1 | ENSBTAP00000027216 | ENSBTAP00000027964 | E1A binding protein p400. | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | 0.996 |
| EP400 | RUVBL2 | ENSBTAP00000027216 | ENSBTAP00000031853 | E1A binding protein p400. | RuvB-like 2; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with oth [...] | 0.996 |
| EP400 | TP53 | ENSBTAP00000027216 | ENSBTAP00000001420 | E1A binding protein p400. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.826 |
| EP400 | TRRAP | ENSBTAP00000027216 | ENSBTAP00000009365 | E1A binding protein p400. | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. | 0.972 |
