Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MIOXInositol oxygenase; Belongs to the myo-inositol oxygenase family. (346 aa)    
Predicted Functional Partners:
AKR1A1
Aldo-keto reductase family 1 member A1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity). Plays an important role in ascorbic acid biosynthesis by catalyzing the reduction of D-glucuronic acid and D-glucurono-gamma-lactone (By similarity). Functions as a detox [...]
   
 
 0.958
IMPA2
Inositol monophosphatase 2.
   
 
 0.956
KL
Klotho.
   
 
  0.915
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase.
     
 0.885
UGT1A1
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
     
  0.881
DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase.
   
 
 0.866
IMPA1
Inositol monophosphatase 1; Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4- diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6- phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates (By similarity). Is equally active with myo-inositol monophosphate and D-galactose 1-phosphate.
   
 
 0.842
ENSBTAP00000071108
Uncharacterized protein.
   
 
 0.842
UGT2A1
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
     
  0.799
KLB
Klotho beta.
   
 
  0.764
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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