| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDK10 | ETS1 | ENSBTAP00000044609 | ENSBTAP00000059608 | Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling. | ETS proto-oncogene 1, transcription factor. | 0.625 |
| CDK10 | ETS2 | ENSBTAP00000044609 | ENSBTAP00000072496 | Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling. | Protein C-ets-2; Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity). | 0.799 |
| CREBBP | ETS1 | ENSBTAP00000005092 | ENSBTAP00000059608 | CREB binding protein. | ETS proto-oncogene 1, transcription factor. | 0.874 |
| CREBBP | ETS2 | ENSBTAP00000005092 | ENSBTAP00000072496 | CREB binding protein. | Protein C-ets-2; Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity). | 0.833 |
| CREBBP | JUN | ENSBTAP00000005092 | ENSBTAP00000005279 | CREB binding protein. | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter; Belongs to the bZIP family. Jun subfamily. | 0.964 |
| CREBBP | MAPK1 | ENSBTAP00000005092 | ENSBTAP00000013623 | CREB binding protein. | Mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.633 |
| CREBBP | MAPK3 | ENSBTAP00000005092 | ENSBTAP00000021507 | CREB binding protein. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.621 |
| CREBBP | SRF | ENSBTAP00000005092 | ENSBTAP00000016981 | CREB binding protein. | Serum response factor. | 0.634 |
| CREBBP | TP53 | ENSBTAP00000005092 | ENSBTAP00000001420 | CREB binding protein. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.997 |
| ELK4 | ETS1 | ENSBTAP00000056094 | ENSBTAP00000059608 | ETS transcription factor ELK4. | ETS proto-oncogene 1, transcription factor. | 0.857 |
| ELK4 | ETS2 | ENSBTAP00000056094 | ENSBTAP00000072496 | ETS transcription factor ELK4. | Protein C-ets-2; Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity). | 0.770 |
| ELK4 | JUN | ENSBTAP00000056094 | ENSBTAP00000005279 | ETS transcription factor ELK4. | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter; Belongs to the bZIP family. Jun subfamily. | 0.481 |
| ELK4 | MAPK1 | ENSBTAP00000056094 | ENSBTAP00000013623 | ETS transcription factor ELK4. | Mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.922 |
| ELK4 | MAPK3 | ENSBTAP00000056094 | ENSBTAP00000021507 | ETS transcription factor ELK4. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.922 |
| ELK4 | SRF | ENSBTAP00000056094 | ENSBTAP00000016981 | ETS transcription factor ELK4. | Serum response factor. | 0.990 |
| ETS1 | CDK10 | ENSBTAP00000059608 | ENSBTAP00000044609 | ETS proto-oncogene 1, transcription factor. | Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling. | 0.625 |
| ETS1 | CREBBP | ENSBTAP00000059608 | ENSBTAP00000005092 | ETS proto-oncogene 1, transcription factor. | CREB binding protein. | 0.874 |
| ETS1 | ELK4 | ENSBTAP00000059608 | ENSBTAP00000056094 | ETS proto-oncogene 1, transcription factor. | ETS transcription factor ELK4. | 0.857 |
| ETS1 | ETS2 | ENSBTAP00000059608 | ENSBTAP00000072496 | ETS proto-oncogene 1, transcription factor. | Protein C-ets-2; Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity). | 0.982 |
| ETS1 | ID1 | ENSBTAP00000059608 | ENSBTAP00000021521 | ETS proto-oncogene 1, transcription factor. | Inhibitor of DNA binding 1, HLH protein. | 0.661 |
