KIF1B protein (Bos taurus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

KIF1B

Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1167 aa)

Predicted Functional Partners:

ENSBTAP00000063814

0.883

KIFC2

0.802

ENSBTAP00000066019

0.799

KLC2

0.790

KIF23

0.716

KIF5B

0.713

KIF15

0.702

KIF21A

0.700

KIF5A

0.686

KLC1

0.679

Your Current Organism:

Bos taurus

NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSBTAP00000063814	ENSBTAP00000066019	ENSBTAP00000063814	ENSBTAP00000066019	Uncharacterized protein.	PH domain-containing protein.	0.937
ENSBTAP00000063814	KIF1B	ENSBTAP00000063814	ENSBTAP00000073585	Uncharacterized protein.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.883
ENSBTAP00000063814	KIF5A	ENSBTAP00000063814	ENSBTAP00000059822	Uncharacterized protein.	Kinesin family member 5A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.443
ENSBTAP00000063814	KIF5B	ENSBTAP00000063814	ENSBTAP00000060512	Uncharacterized protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.458
ENSBTAP00000066019	ENSBTAP00000063814	ENSBTAP00000066019	ENSBTAP00000063814	PH domain-containing protein.	Uncharacterized protein.	0.937
ENSBTAP00000066019	KIF1B	ENSBTAP00000066019	ENSBTAP00000073585	PH domain-containing protein.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.799
KIF15	KIF1B	ENSBTAP00000053783	ENSBTAP00000073585	Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.702
KIF15	KIF21A	ENSBTAP00000053783	ENSBTAP00000006351	Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin family member 21A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.705
KIF15	KIF23	ENSBTAP00000053783	ENSBTAP00000013163	Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin family member 23; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.882
KIF15	KIF5A	ENSBTAP00000053783	ENSBTAP00000059822	Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin family member 5A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.650
KIF15	KIF5B	ENSBTAP00000053783	ENSBTAP00000060512	Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.648
KIF15	KIFC2	ENSBTAP00000053783	ENSBTAP00000072984	Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin family member C2.	0.776
KIF15	KLC1	ENSBTAP00000053783	ENSBTAP00000023001	Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	KLC1 protein.	0.466
KIF15	KLC2	ENSBTAP00000053783	ENSBTAP00000025752	Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin light chain 2.	0.472
KIF1B	ENSBTAP00000063814	ENSBTAP00000073585	ENSBTAP00000063814	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.883
KIF1B	ENSBTAP00000066019	ENSBTAP00000073585	ENSBTAP00000066019	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	PH domain-containing protein.	0.799
KIF1B	KIF15	ENSBTAP00000073585	ENSBTAP00000053783	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.702
KIF1B	KIF21A	ENSBTAP00000073585	ENSBTAP00000006351	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin family member 21A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.700
KIF1B	KIF23	ENSBTAP00000073585	ENSBTAP00000013163	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin family member 23; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.716
KIF1B	KIF5A	ENSBTAP00000073585	ENSBTAP00000059822	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin family member 5A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.686

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Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.845

expected number of edges:

10

PPI enrichment p-value:

0.000782

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007264

Small GTPase mediated signal transduction

6 of 207

1.64

1.94

2.04e-05

GO:0007265

Ras protein signal transduction

5 of 152

1.69

1.74

0.00012

GO:0035556

Intracellular signal transduction

9 of 1154

1.07

1.13

2.04e-05

GO:0071803

Positive regulation of podosome assembly

2 of 9

2.52

0.86

0.0270

GO:1902117

Positive regulation of organelle assembly

3 of 72

1.8

0.85

0.0226

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070290

N-acylphosphatidylethanolamine-specific phospholipase D activity

2 of 3

3.0

1.07

0.0119

GO:0004630

Phospholipase D activity

2 of 3

3.0

1.07

0.0119

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000145

Exocyst

2 of 16

2.27

0.72

0.0472

GO:0071944

Cell periphery

10 of 4170

0.56

0.39

0.0137

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:12878

Mixed, incl. Rho (Ras homology) subfamily of Ras-like small GTPases, and RHOU GTPase cycle

4 of 38

2.2

2.23

4.34e-05

CL:12871

Mixed, incl. Small GTPase mediated signal transduction, and RHO GTPases Activate WASPs and WAVEs

5 of 193

1.59

1.67

0.00010

CL:11806

Phospholipase D. Active site motifs.

2 of 5

2.78

1.33

0.0039

CL:20320

Exocyst

2 of 6

2.7

1.28

0.0046

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04014

Ras signaling pathway

10 of 225

1.83

4.82

1.04e-15

map05212

Pancreatic cancer

6 of 75

2.08

4.05

9.00e-10

map04072

Phospholipase D signaling pathway

5 of 154

1.69

2.25

2.96e-06

map05210

Colorectal cancer

4 of 89

1.83

2.13

2.09e-05

map05231

Choline metabolism in cancer

4 of 99

1.78

2.05

2.63e-05

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0004012

ROS cell

2 of 2

3.18

1.28

0.0049

BTO:0003432

EL-4 cell

2 of 2

3.18

1.28

0.0049

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0098981

Cholinergic synapse

2 of 5

2.78

1.0

0.0152

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00229

Guanine nucleotide exchange factor for Ras-like GTPases

3 of 18

2.4

1.95

0.00022

SM00147

Guanine nucleotide exchange factor for Ras-like small GTPases

3 of 25

2.26

1.87

0.00027

SM00314

Ras association (RalGDS/AF-6) domain

3 of 28

2.21

1.86

0.00027

SM00155

Phospholipase D. Active site motifs.

2 of 5

2.78

1.54

0.0016

SM00312

PhoX homologous domain, present in p47phox and p40phox.

2 of 34

1.95

0.75

0.0386

(more ...)

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