Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
H2BC12Histone H2B; Belongs to the histone H2B family. (126 aa)    
Predicted Functional Partners:
LOC102180307
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 0.976
LOC102172954
Histone H4.
   
 0.976
LOC106503502
Histone H4.
   
 0.976
LOC108636047
Histone H4.
   
 0.976
LOC106503503
Histone H4.
   
 0.976
H2AC6
Histone H2A; Belongs to the histone H2A family.
  
 0.973
H2AX
Histone H2A; Belongs to the histone H2A family.
  
 0.968
H3-4
Histone H3; Belongs to the histone H3 family.
   
 0.963
LOC102185882
Histone H3; Belongs to the histone H3 family.
   
 0.960
LOC102180554
Histone H3; Belongs to the histone H3 family.
   
 0.960
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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