Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
KDM5ALysine demethylase 5A. (1690 aa)    
Predicted Functional Partners:
KDM6A
Lysine demethylase 6A.
   
 0.879
ATP5PO
Uncharacterized protein.
  
 0.843
ATP5F1C
ATP synthase subunit gamma.
  
 0.843
ATP5F1D
ATP synthase F1 subunit delta.
  
 0.843
KDM2B
Lysine demethylase 2B.
   
 0.841
KDM6B
Lysine demethylase 6B.
   
 0.832
KDM1A
Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.
    
 
 0.821
EZH2
Enhancer of zeste 2 polycomb repressive complex 2 subunit.
   
 0.807
KDM3A
Lysine demethylase 3A.
   
 
 0.803
KDM2A
Lysine demethylase 2A.
   
 0.794
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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