Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PAK1Non-specific serine/threonine protein kinase. (544 aa)    
Predicted Functional Partners:
CDC42
Uncharacterized protein.
   
 0.984
PAK2
Non-specific serine/threonine protein kinase.
   
  0.984
NCK2
Cytoplasmic protein.
    
 0.981
NCK1
Cytoplasmic protein.
    
 0.981
RAC2
Rac family small GTPase 2.
   
 0.973
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor 6.
   
 0.972
FLNA
Filamin A.
    
 0.961
TIAM1
T cell lymphoma invasion and metastasis 1.
   
 0.953
LIMK1
LIM domain kinase 1.
    
0.953
RAF1
Raf-1 proto-oncogene, serine/threonine kinase.
    
 0.943
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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