Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TOX4TOX high mobility group box family member 4. (621 aa)    
Predicted Functional Partners:
WDR82
WD_REPEATS_REGION domain-containing protein.
    
 
 0.910
PPP1CB
Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.
   
 0.888
PPP1R10
Protein phosphatase 1 regulatory subunit 10.
   
 0.840
TOX3
TOX high mobility group box family member 3.
   
  
 0.820
PPP1CA
Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.
   
  0.778
PPP1CC
Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.
   
  0.778
OR10G3
Olfactory receptor family 10 subfamily G member 3.
      
 0.772
SUPT16H
SPT16 homolog, facilitates chromatin remodeling subunit.
   
 0.731
RNF212B
Ring finger protein 212B.
      
 0.706
CHD8
Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...]
   
 0.689
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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