Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
TNFSF13BTumor necrosis factor superfamily member 13b; Belongs to the tumor necrosis factor family. (280 aa)    
Predicted Functional Partners:
TNFRSF13C
TNF receptor superfamily member 13C.
    
 0.997
TNFRSF17
TNF receptor superfamily member 17.
    
 0.994
TNFSF11
Tumor necrosis factor ligand superfamily member.
    
 0.878
TNFSF13
TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.
   
 
0.860
AKTIP
AKT interacting protein.
    
 
 0.854
TNFSF12
TNF superfamily member 12; Belongs to the tumor necrosis factor family.
    
 0.837
FAM160A2
Family with sequence similarity 160 member A2.
    
   0.833
CD40LG
CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
     
 0.813
TNF
Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]
   
 
 0.781
MAP3K14
Mitogen-activated protein kinase kinase kinase 14.
     
 0.730
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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