Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)    
Predicted Functional Partners:
CDK5
Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.
    
 0.997
MAPT
Microtubule-associated protein.
   
 0.948
CAPN2
Calpain 2; Belongs to the peptidase C2 family.
   
 0.925
CAPN1
Uncharacterized protein; Belongs to the peptidase C2 family.
   
 0.925
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.786
MAP2
Microtubule-associated protein.
   
 0.680
CAPN8
Calpain 8; Belongs to the peptidase C2 family.
   
 0.644
CAPN14
Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family.
   
 0.641
CDK2
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
    
 
 0.619
TP73
Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
    
 0.603
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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