TMEM37 protein (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TMEM37

Transmembrane protein 37. (203 aa)

Predicted Functional Partners:

SLC26A4

0.658

CFTR

0.517

ITPKB

0.495

CYB5R2

0.483

ABCD2

0.452

GLIS2

0.445

SLITRK6

0.438

SLC17A3

0.438

CHI3L2

0.435

LOC108633177

0.434

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCD2	TMEM37	ENSCHIP00000002112	ENSCHIP00000004366	ATP binding cassette subfamily D member 2.	Transmembrane protein 37.	0.452
CFTR	SLC26A4	ENSCHIP00000018957	ENSCHIP00000031802	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	0.725
CFTR	TMEM37	ENSCHIP00000018957	ENSCHIP00000004366	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	Transmembrane protein 37.	0.517
CHI3L2	TMEM37	ENSCHIP00000009074	ENSCHIP00000004366	Chitinase 3 like 2; Belongs to the glycosyl hydrolase 18 family.	Transmembrane protein 37.	0.435
CYB5R2	ITPKB	ENSCHIP00000031887	ENSCHIP00000015865	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Kinase; Belongs to the inositol phosphokinase (IPK) family.	0.468
CYB5R2	TMEM37	ENSCHIP00000031887	ENSCHIP00000004366	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Transmembrane protein 37.	0.483
GLIS2	ITPKB	ENSCHIP00000025400	ENSCHIP00000015865	GLIS family zinc finger 2.	Kinase; Belongs to the inositol phosphokinase (IPK) family.	0.436
GLIS2	TMEM37	ENSCHIP00000025400	ENSCHIP00000004366	GLIS family zinc finger 2.	Transmembrane protein 37.	0.445
ITPKB	CYB5R2	ENSCHIP00000015865	ENSCHIP00000031887	Kinase; Belongs to the inositol phosphokinase (IPK) family.	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.468
ITPKB	GLIS2	ENSCHIP00000015865	ENSCHIP00000025400	Kinase; Belongs to the inositol phosphokinase (IPK) family.	GLIS family zinc finger 2.	0.436
ITPKB	TMEM37	ENSCHIP00000015865	ENSCHIP00000004366	Kinase; Belongs to the inositol phosphokinase (IPK) family.	Transmembrane protein 37.	0.495
LOC108633177	TMEM37	ENSCHIP00000006307	ENSCHIP00000004366	GB1/RHD3-type G domain-containing protein.	Transmembrane protein 37.	0.434
SLC17A3	TMEM37	ENSCHIP00000022544	ENSCHIP00000004366	Solute carrier family 17 member 3.	Transmembrane protein 37.	0.438
SLC26A4	CFTR	ENSCHIP00000031802	ENSCHIP00000018957	Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	0.725
SLC26A4	TMEM37	ENSCHIP00000031802	ENSCHIP00000004366	Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	Transmembrane protein 37.	0.658
SLITRK6	TMEM37	ENSCHIP00000007832	ENSCHIP00000004366	SLIT and NTRK like family member 6.	Transmembrane protein 37.	0.438
TMEM37	ABCD2	ENSCHIP00000004366	ENSCHIP00000002112	Transmembrane protein 37.	ATP binding cassette subfamily D member 2.	0.452
TMEM37	CFTR	ENSCHIP00000004366	ENSCHIP00000018957	Transmembrane protein 37.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	0.517
TMEM37	CHI3L2	ENSCHIP00000004366	ENSCHIP00000009074	Transmembrane protein 37.	Chitinase 3 like 2; Belongs to the glycosyl hydrolase 18 family.	0.435
TMEM37	CYB5R2	ENSCHIP00000004366	ENSCHIP00000031887	Transmembrane protein 37.	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.483