node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD14 | LY96 | ENSCHIP00000008044 | ENSCHIP00000009798 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Lymphocyte antigen 96. | 0.982 |
CD14 | TLR2 | ENSCHIP00000008044 | ENSCHIP00000031619 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.957 |
CD14 | TLR4 | ENSCHIP00000008044 | ENSCHIP00000019512 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | TIR domain-containing protein; Belongs to the Toll-like receptor family. | 0.991 |
CD14 | TLR6 | ENSCHIP00000008044 | ENSCHIP00000025720 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Toll-like receptor. | 0.554 |
CD14 | TRAF6 | ENSCHIP00000008044 | ENSCHIP00000015162 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.480 |
HMGB1 | LY96 | ENSCHIP00000019478 | ENSCHIP00000009798 | Uncharacterized protein. | Lymphocyte antigen 96. | 0.843 |
HMGB1 | MYD88 | ENSCHIP00000019478 | ENSCHIP00000018063 | Uncharacterized protein. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.762 |
HMGB1 | TIRAP | ENSCHIP00000019478 | ENSCHIP00000031677 | Uncharacterized protein. | TIR domain containing adaptor protein. | 0.571 |
HMGB1 | TLR2 | ENSCHIP00000019478 | ENSCHIP00000031619 | Uncharacterized protein. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.995 |
HMGB1 | TLR4 | ENSCHIP00000019478 | ENSCHIP00000019512 | Uncharacterized protein. | TIR domain-containing protein; Belongs to the Toll-like receptor family. | 0.999 |
HMGB1 | TLR6 | ENSCHIP00000019478 | ENSCHIP00000025720 | Uncharacterized protein. | Toll-like receptor. | 0.969 |
LY96 | CD14 | ENSCHIP00000009798 | ENSCHIP00000008044 | Lymphocyte antigen 96. | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | 0.982 |
LY96 | HMGB1 | ENSCHIP00000009798 | ENSCHIP00000019478 | Lymphocyte antigen 96. | Uncharacterized protein. | 0.843 |
LY96 | MYD88 | ENSCHIP00000009798 | ENSCHIP00000018063 | Lymphocyte antigen 96. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.984 |
LY96 | TICAM1 | ENSCHIP00000009798 | ENSCHIP00000023900 | Lymphocyte antigen 96. | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | 0.591 |
LY96 | TICAM2 | ENSCHIP00000009798 | ENSCHIP00000008157 | Lymphocyte antigen 96. | TIR domain-containing protein. | 0.758 |
LY96 | TIRAP | ENSCHIP00000009798 | ENSCHIP00000031677 | Lymphocyte antigen 96. | TIR domain containing adaptor protein. | 0.961 |
LY96 | TLR2 | ENSCHIP00000009798 | ENSCHIP00000031619 | Lymphocyte antigen 96. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.923 |
LY96 | TLR4 | ENSCHIP00000009798 | ENSCHIP00000019512 | Lymphocyte antigen 96. | TIR domain-containing protein; Belongs to the Toll-like receptor family. | 0.999 |
LY96 | TLR6 | ENSCHIP00000009798 | ENSCHIP00000025720 | Lymphocyte antigen 96. | Toll-like receptor. | 0.842 |