Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
caiCcrotonobetaine/carnitine-CoA ligase; Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine. (517 aa)    
Predicted Functional Partners:
caiA
Putative acyl-CoA dehydrogenase, carnitine metabolism; Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA; Belongs to the acyl-CoA dehydrogenase family.
  
 0.983
caiB
L-carnitine dehydratase; Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L- carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA (By similarity); Belongs to the CoA-transferase III family. CaiB subfamily.
 
  
 0.980
caiD
Carnitine racemase; Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA.
 0.975
entF
Enterobactin synthetase, component F (nonribosomal peptide synthetase); Similar to E. coli ATP-dependent serine activating enzyme (may be part of enterobactin synthase as component F) (AAC73687.1); Blastp hit to AAC73687.1 (1293 aa), 79% identity in aa 1 - 1293.
  
0.950
caiT
Putative BCCT family betaine/carnitine/choline transport protein; Catalyzes the exchange of L-carnitine for gamma-butyrobetaine and related betaines.
 
  
 0.888
fixC
Related to carnitine metabolism protein; Could be part of an electron transfer system required for anaerobic carnitine reduction; Belongs to the ETF-QO/FixC family.
 
  
 0.876
STM0660
Putative cytoplasmic protein.
      
 0.859
caiE
Stimulates carnitine racemase activity of CaiD and CaiB activity; Overproduction of CaiE stimulates the activity of CaiB and CaiD; Belongs to the transferase hexapeptide repeat family.
  
  
 0.844
fixA
Putative flavoprotein reductase, carnitine metabolism; Required for anaerobic carnitine reduction. May bring reductant to CaiA.
 
  
 0.772
fixB
Putative electron transfer flavoprotein, carnitine metabolism; Required for anaerobic carnitine reduction. May bring reductant to CaiA.
 
  
 0.756
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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