Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
yabFPutative NAD(P)H oxidoreductase; Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefC. Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC; Belongs to the NAD(P)H dehydrogenase (quinone) family. KefF subfamily. (176 aa)    
Predicted Functional Partners:
kefC
CPA2 family K+ efflux antiporter, glutathione-regulated; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport.
 
 
 0.997
kefB
CPA2 family K+:H+ antiporter; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport.
 
 
 0.983
yjjX
Putative cytoplasmic protein; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
      
 0.858
yaaU
Similar to E. coli putative transport protein (AAC73156.1); Blastp hit to AAC73156.1 (443 aa), 86% identity in aa 1 - 439.
     
 0.774
rihC
Putative purine nucleoside hydrolase; Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity.
   
  
 0.729
ycaO
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73991.1); Blastp hit to AAC73991.1 (589 aa), 93% identity in aa 4 - 589.
      
 0.671
rhtC
RhtB family threonine efflux protein; Conducts the efflux of threonine; Belongs to the Rht family.
      
 0.634
yedF
Putative transcriptional regulator; Hypothetical 8.6 Kda protein in amyA-fliE intergenic region (ORF 9). (SW:YEDF_ECOLI); Belongs to the sulfur carrier protein TusA family.
   
  
 0.478
yohI
Putative nitrogen regulation protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily.
      
 0.478
mdaB
NADPH specific quinone oxidoreductase; Drug modulator; similar to E. coli modulator of drug activity B (AAC76064.1); Blastp hit to AAC76064.1 (193 aa), 92% identity in aa 1 - 192.
 
   
 0.468
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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