Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
tbpAThiamine-binding periplasmic protein; Part of the ABC transporter complex ThiBPQ involved in thiamine import. Is also involved in thiamine pyrophosphate transport. (327 aa)    
Predicted Functional Partners:
yabK
Putative binding-protein-dependent transport system inner membrane component; Part of the ABC transporter complex ThiBPQ involved in thiamine import. Probably responsible for the translocation of the substrate across the membrane (Probable). Is also involved in thiamine pyrophosphate transport.
 
 
 0.996
yabJ
Putative ABC-transport protein; Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system (Probable). Is also involved in thiamine pyrophosphate (TPP) transport. Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family.
 
 
 0.991
yabN
Putative periplasmic binding protein of transport system; Activates the small RNA gene sgrS under glucose-phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain.
 
   
 0.789
oadB
Oxaloacetate decarboxylase beta chain; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
      
 0.721
yabI
Putative DedA family membrane protein; Similar to E. coli orf, hypothetical protein (AAC73176.1); Blastp hit to AAC73176.1 (254 aa), 89% identity in aa 1 - 253.
   
  
 0.650
thiM
Hydoxyethylthiazole kinase (THZ kinase); Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
   
  
 0.523
yaeH
Similar to E. coli putative structural protein (AAC73274.1); Blastp hit to AAC73274.1 (128 aa), 95% identity in aa 1 - 128; Belongs to the UPF0325 family.
  
     0.487
yfeH
Putative Na+-dependent transporter; Similar to E. coli putative cytochrome oxidase (AAC75463.1); Blastp hit to AAC75463.1 (332 aa), 90% identity in aa 1 - 332.
  
     0.479
yhhQ
Putative integral membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
  
    0.464
eutN
Putative detox protein in ethanolamine utilization; May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place; To cyanobacterial carbon dioxide concentrating mechanism protein CcmL.
      
 0.431
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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