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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuOPutative LysR family transcriptional regulator; Probable activator protein in leuabcd operon. (SW:LEUO_SALTY); Belongs to the LysR transcriptional regulatory family. (314 aa)    
Predicted Functional Partners:
bglJ
Transcriptional regulator (activator) of bgl operon; LuxR/UhpA family; similar to E. coli 2-component transcriptional regulator (AAC77322.1); Blastp hit to AAC77322.1 (225 aa), 63% identity in aa 1 - 223.
  
  
 0.916
yjjQ
Putative LuxR/UhpA family transcriptional regulator; Similar to E. coli putative regulator (AAC77321.1); Blastp hit to AAC77321.1 (241 aa), 66% identity in aa 1 - 241.
   
  
 0.825
cadC
OmpR family; similar to E. coli transcriptional activator of cad operon (AAC77094.1); Blastp hit to AAC77094.1 (512 aa), 58% identity in aa 1 - 512.
  
   
 0.820
slyA
MarR family transcriptional regulator for hemolysin; Transcription regulator that can specifically activate or repress expression of target genes. Required for virulence and survival in the macrophage environment. Probably activates expression of ispA, xseB genes, and of omp operon.
   
  
 0.762
celD
AraC/XylS family; similar to E. coli negative transcriptional regulator of cel operon (AAC74805.1); Blastp hit to AAC74805.1 (280 aa), 85% identity in aa 1 - 280.
  
  
 0.738
STM3736
Similar to E. coli putative transcriptional regulator LYSR-type (AAC73730.1); Blastp hit to AAC73730.1 (266 aa), 25% identity in aa 2 - 219; Belongs to the LysR transcriptional regulatory family.
  
    0.702
lrp
Regulator for lrp regulon and high-affinity branched-chain amino acid transport system; Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes.
   
  
 0.700
sgcX
Putative cellulase protein; Similar to E. coli putative lyase/synthase (AAC77261.1); Blastp hit to AAC77261.1 (383 aa), 84% identity in aa 11 - 382.
      
 0.700
hilD
Regulatory helix-turn-helix proteins, araC family; HilD (gi|4455108).
  
  
 0.661
crp
Catabolite activator protein (CAP); A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity).
   
  
 0.660
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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