Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
leuOPutative LysR family transcriptional regulator; Probable activator protein in leuabcd operon. (SW:LEUO_SALTY); Belongs to the LysR transcriptional regulatory family. (314 aa)    
Predicted Functional Partners:
bglJ
Transcriptional regulator (activator) of bgl operon; LuxR/UhpA family; similar to E. coli 2-component transcriptional regulator (AAC77322.1); Blastp hit to AAC77322.1 (225 aa), 63% identity in aa 1 - 223.
  
  
 0.918
cadC
OmpR family; similar to E. coli transcriptional activator of cad operon (AAC77094.1); Blastp hit to AAC77094.1 (512 aa), 58% identity in aa 1 - 512.
  
   
 0.807
slyA
MarR family transcriptional regulator for hemolysin; Transcription regulator that can specifically activate or repress expression of target genes. Required for virulence and survival in the macrophage environment. Probably activates expression of ispA, xseB genes, and of omp operon.
      
 0.769
yjjQ
Putative LuxR/UhpA family transcriptional regulator; Similar to E. coli putative regulator (AAC77321.1); Blastp hit to AAC77321.1 (241 aa), 66% identity in aa 1 - 241.
   
  
 0.764
celD
AraC/XylS family; similar to E. coli negative transcriptional regulator of cel operon (AAC74805.1); Blastp hit to AAC74805.1 (280 aa), 85% identity in aa 1 - 280.
  
  
 0.735
sgcX
Putative cellulase protein; Similar to E. coli putative lyase/synthase (AAC77261.1); Blastp hit to AAC77261.1 (383 aa), 84% identity in aa 11 - 382.
      
 0.717
hilD
Regulatory helix-turn-helix proteins, araC family; HilD (gi|4455108).
  
   
 0.716
STM3736
Similar to E. coli putative transcriptional regulator LYSR-type (AAC73730.1); Blastp hit to AAC73730.1 (266 aa), 25% identity in aa 2 - 219; Belongs to the LysR transcriptional regulatory family.
  
    0.704
araC
Transcriptional regulator (AraC/XylS family) for ara operon; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose.
  
   
 0.699
crp
Catabolite activator protein (CAP); A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity).
    
 
 0.654
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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