STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fruRTranscriptional repressor of fru operon and others; Global transcriptional regulator, which plays an important role in the regulation of carbon metabolism. (334 aa)    
Predicted Functional Partners:
fruF
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport.
 
 
 
 0.906
ilvH
Acetolactate synthase isozyme III small subunit. (SW:ILVH_SALTY).
    
 0.863
fruK
Similar to E. coli fructose-1-phosphate kinase (AAC75229.1); Blastp hit to AAC75229.1 (312 aa), 98% identity in aa 1 - 312; Belongs to the carbohydrate kinase PfkB family.
 
   
 0.863
STM3633
Putative bacterial regulatory protein; lacI family; similar to E. coli regulator for rbs operon (AAC76776.1); Blastp hit to AAC76776.1 (330 aa), 27% identity in aa 2 - 304.
  
   
 0.818
fruA
Fructose-specific transport protein; Sugar Specific PTS system; similar to E. coli PTS system, fructose-specific transport protein (AAC75228.1); Blastp hit to AAC75228.1 (563 aa), 92% identity in aa 1 - 563.
     
 0.794
ptsH
Phosphohistidinoprotein-hexose phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.
    
 
 0.757
ilvI
Acetolactate synthase isozyme III large subunit. (SW:ILVI_SALTY).
    
 0.750
crp
Catabolite activator protein (CAP); A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity).
    
 
 0.734
ptsA
General PTS family enzyme I; Similar to E. coli PEP-protein phosphotransferase system enzyme I (AAC76929.1); Blastp hit to AAC76929.1 (711 aa), 90% identity in aa 1 - 711.
   
 
 0.631
gltB
Similar to E. coli glutamate synthase, large subunit (AAC76244.1); Blastp hit to AAC76244.1 (1517 aa), 95% identity in aa 32 - 1517.
    
 
 0.593
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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