STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aroPAPC family aromatic amino acid transporter; Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan); Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. (457 aa)    
Predicted Functional Partners:
tyrB
Tyrosine repressible; aromatic-amino-acid aminotransferase. (SW:TYRB_SALTY); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
   
  
 0.847
tyrP
HAAAP family tyrosine-specific transport protein; Similar to E. coli tyrosine-specific transport system (AAC74977.1); Blastp hit to AAC74977.1 (403 aa), 88% identity in aa 1 - 403.
      
 0.836
mtr
Similar to E. coli tryptophan-specific transport protein (AAC76195.1); Blastp hit to AAC76195.1 (414 aa), 94% identity in aa 1 - 414.
      
 0.731
tyrR
Transcriptional regulatory protein TyrR; Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino acids (phenylalanine, tyrosine and tryptophan). These amino acids are suggested to act as co-effectors which bind to the TyrR protein to form an active regulatory protein. In most cases TyrR causes negative regulation, but positive effects on the tyrP gene have been observed at high phenylalani [...]
      
 0.718
nadC
Quinolinate phosphoribosyltransferase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
      
 0.621
aroG
3-deoxy-D-arabinoheptulosonate-7-phosphate synthase (DAHP synthetase, phenylalanine repressible); Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP).
   
  
 0.585
alaE
Putative inner membrane protein; Exports L-alanine; Belongs to the AlaE exporter family.
   
  
 0.578
pdhR
Transcriptional repressor for pyruvate dehydrogenase complex (GntR family); Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd.
     
 0.535
STM0149
Putative permease of the Na+:galactoside symporter family; Hypothetical protein (gi|7688349).
       0.530
ygeD
Putative efflux protein; Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell; Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family.
      
 0.521
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.