| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| crp | yacL | STM3466 | STM0160 | Catabolite activator protein (CAP); A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity). | Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73230.1); Blastp hit to AAC73230.1 (136 aa), 85% identity in aa 17 - 135; Belongs to the UPF0231 family. | 0.653 |
| crp | yhfK | STM3466 | STM3467 | Catabolite activator protein (CAP); A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity). | Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC76383.1); Blastp hit to AAC76383.1 (696 aa), 86% identity in aa 1 - 695. | 0.771 |
| trpR | wecF-2 | STM4583 | STM3927 | Transcriptional repressor for trp operon and aroH; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity). | Putative inner membrane protein; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis; Belongs to the glycosyltransferase 56 family. | 0.652 |
| trpR | wzxE | STM4583 | STM3926 | Transcriptional repressor for trp operon and aroH; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity). | O-antigen translocase in LPS biosyntesis; Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA- Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA); Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family. | 0.455 |
| trpR | yacL | STM4583 | STM0160 | Transcriptional repressor for trp operon and aroH; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity). | Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73230.1); Blastp hit to AAC73230.1 (136 aa), 85% identity in aa 17 - 135; Belongs to the UPF0231 family. | 0.728 |
| trpR | ycdY | STM4583 | STM1137 | Transcriptional repressor for trp operon and aroH; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity). | Similar to E. coli putative oxidoreductase component (AAC74119.1); Blastp hit to AAC74119.1 (184 aa), 86% identity in aa 1 - 184. | 0.762 |
| trpR | yhfK | STM4583 | STM3467 | Transcriptional repressor for trp operon and aroH; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity). | Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC76383.1); Blastp hit to AAC76383.1 (696 aa), 86% identity in aa 1 - 695. | 0.506 |
| trpR | yhjJ | STM4583 | STM3613 | Transcriptional repressor for trp operon and aroH; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity). | Putative Zn-dependent peptidase; Protein YHJJ precursor. (SW:YHJJ_SALTY); Belongs to the peptidase M16 family. | 0.672 |
| trpR | yraM | STM4583 | STM3264 | Transcriptional repressor for trp operon and aroH; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity). | Putative transglycosylase; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Belongs to the LpoA family. | 0.718 |
| wecF-2 | trpR | STM3927 | STM4583 | Putative inner membrane protein; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis; Belongs to the glycosyltransferase 56 family. | Transcriptional repressor for trp operon and aroH; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity). | 0.652 |
| wecF-2 | wzxE | STM3927 | STM3926 | Putative inner membrane protein; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis; Belongs to the glycosyltransferase 56 family. | O-antigen translocase in LPS biosyntesis; Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA- Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA); Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family. | 0.994 |
| wecF-2 | yacL | STM3927 | STM0160 | Putative inner membrane protein; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis; Belongs to the glycosyltransferase 56 family. | Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73230.1); Blastp hit to AAC73230.1 (136 aa), 85% identity in aa 17 - 135; Belongs to the UPF0231 family. | 0.701 |
| wecF-2 | ycdY | STM3927 | STM1137 | Putative inner membrane protein; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis; Belongs to the glycosyltransferase 56 family. | Similar to E. coli putative oxidoreductase component (AAC74119.1); Blastp hit to AAC74119.1 (184 aa), 86% identity in aa 1 - 184. | 0.761 |
| wecF-2 | yhfK | STM3927 | STM3467 | Putative inner membrane protein; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis; Belongs to the glycosyltransferase 56 family. | Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC76383.1); Blastp hit to AAC76383.1 (696 aa), 86% identity in aa 1 - 695. | 0.566 |
| wecF-2 | yhjJ | STM3927 | STM3613 | Putative inner membrane protein; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis; Belongs to the glycosyltransferase 56 family. | Putative Zn-dependent peptidase; Protein YHJJ precursor. (SW:YHJJ_SALTY); Belongs to the peptidase M16 family. | 0.751 |
| wecF-2 | yraM | STM3927 | STM3264 | Putative inner membrane protein; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis; Belongs to the glycosyltransferase 56 family. | Putative transglycosylase; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Belongs to the LpoA family. | 0.640 |
| wzxE | trpR | STM3926 | STM4583 | O-antigen translocase in LPS biosyntesis; Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA- Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA); Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family. | Transcriptional repressor for trp operon and aroH; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity). | 0.455 |
| wzxE | wecF-2 | STM3926 | STM3927 | O-antigen translocase in LPS biosyntesis; Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA- Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA); Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family. | Putative inner membrane protein; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis; Belongs to the glycosyltransferase 56 family. | 0.994 |
| wzxE | yacL | STM3926 | STM0160 | O-antigen translocase in LPS biosyntesis; Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA- Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA); Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family. | Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73230.1); Blastp hit to AAC73230.1 (136 aa), 85% identity in aa 17 - 135; Belongs to the UPF0231 family. | 0.563 |
| wzxE | ycdY | STM3926 | STM1137 | O-antigen translocase in LPS biosyntesis; Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA- Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA); Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family. | Similar to E. coli putative oxidoreductase component (AAC74119.1); Blastp hit to AAC74119.1 (184 aa), 86% identity in aa 1 - 184. | 0.649 |
