STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dtnKPutative inner membrane protein; Catalyzes the ATP-dependent phosphorylation of D-threonate to D-threonate 4-phosphate. Can also phosphorylate 4- hydroxy-L-threonine, with lower efficiency. This side reaction may serve to deal with the toxicity of 4-hydroxy-L-threonine by converting it into 4-hydroxy-L-threonine 4-phosphate, a useful product that can be used by PdxA2. Belongs to the four-carbon acid sugar kinase family. (423 aa)    
Predicted Functional Partners:
pdxA2
Pyridoxine phosphate biosynthetic protein; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP). Can also use 4-hydroxy-L-threonine 4-phosphate as substrate. Belongs to the PdxA family. PdxA2 subfamily.
     0.992
kdgT
2-keto-3-deoxygluconate permease; The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity); Belongs to the KdgT transporter family.
 
   
 0.948
pdxA
NAD-dependent dehydrogenase/carboxylase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
     0.881
STM0164
Similar to E. coli putative DEOR-type transcriptional regulator (AAC75777.1); Blastp hit to AAC75777.1 (265 aa), 34% identity in aa 16 - 265.
 
    0.828
kdgT2
Putative permease; The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity); Belongs to the KdgT transporter family.
 
   
 0.774
ygbL
Similar to E. coli putative epimerase/aldolase (AAC75780.1); Blastp hit to AAC75780.1 (212 aa), 85% identity in aa 1 - 211.
  
 0.602
STM0650
Similar to E. coli putative hydrolase (AAC76162.1); Blastp hit to AAC76162.1 (523 aa), 35% identity in aa 167 - 521, 32% identity in aa 119 - 223.
 
     0.474
yacL
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73230.1); Blastp hit to AAC73230.1 (136 aa), 85% identity in aa 17 - 135; Belongs to the UPF0231 family.
       0.434
STM0649
Putative hydrolase N-terminus; Similar to E. coli altronate hydrolase (AAC76126.1); Blastp hit to AAC76126.1 (495 aa), 38% identity in aa 4 - 82.
 
     0.434
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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