STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cueOPutative multicopper oxidase; Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm (By similarity). (536 aa)    
Predicted Functional Partners:
cueR
Putative heavy metal transcriptional repressor (MerR family); Regulates the transcription of the copA and cuiD (cueO) genes. Detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations.
 
  
 0.968
zntA
P-type ATPase family; Pb/Cd/Zn/Hg transporting ATPase; similar to E. coli zinc-transporting ATPase (AAC76494.1); Blastp hit to AAC76494.1 (732 aa), 84% identity in aa 1 - 731.
  
  
 0.920
STM3650
Putative periplasmic or exported protein.
  
  
 0.920
copA
Putative copper-transporting ATPase; [Copper-exporting P-type ATPase]: Involved in Cu(+) export (By similarity). Essential for copper tolerance under both aerobic and anaerobic conditions.
 
 
 0.892
copS
Copper resistance; Member of a two-component regulatory system.
      
 0.891
ybgR
Putative CDF family transport protein; Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
 
   
 0.783
STM0355
Putative copper chaperone.
  
 
 0.756
yiiP
Putative CDF family transport protein; Cation-efflux transporter that may have a role in detoxification.
  
 
 0.727
cutA
Putative periplasmic divalent cation tolerance protein; Involved in resistance toward heavy metals. Belongs to the CutA family.
      
 0.705
sodC-2
Copper/zinc superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family.
    
 
 0.703
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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